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SARS-CoV-2 Variants Research Reagents

The Omicron variant has been designated as a variant of concern (VOC) by the WHO. Omicron is now designated as the most contagious variant with at least twice the spreading speed compared to the Delta variant according to scientists in southern Africa. Omicron variant spike protein includes mutations, deletions, and insertions, which are related to transmissibility increase, immune escape, and resistance to monoclonal antibody treatments.

To enable a proteomic analysis of SARS-CoV-2 protein expression, ProSci R&D has created SARS-CoV-2 point mutation-specific antibodies, for Omicron (9793, 9805, PM-9375, 9091), Delta (9689, 9463, PM-9677), Gamma (9573, PM-9590), and Alpha (9359, PM-9371) variants.

ProSci further offers Omicron variant recombinant proteins, including Spike Trimer (21-845), Spike S1 (21-846, 95-129) and RBD proteins (95-128, 21-801, 21-844) with His-Avi tag, and Nucleocapsid protein (21-850). We also offer Delta variant Spike S1 (95-127) and RBD (95-126, 21-831) proteins with His-Avi tag. These are proteomics tools to interrogate viral and VLP expression.

SARS-CoV-2 variants reagents from ProSci

Select Your SARS-CoV-2 Variant of Concern

Omicron

SARS-CoV-2 Omicron Variant

Proteome of SARS-CoV-2 Omicron variant
Antibodies
ProductCat. No.ApplicationClonalitySpecies
SARS-CoV-2 (COVID-19) Spike Q493R G496S Q498R N501Y Y505H Antibody (Omicron)9805ELISA, WBPolyclonalRabbit
SARS-CoV-2 (COVID-19) Spike P681H Antibody (Omicron Variant)PM-9375ELISAMonoclonalMouse
SARS-CoV-2 (COVID-19) Spike G142D Δ143-145VYY Antibody (Omicron)9793ELISA, WBPolyclonalRabbit
Recombinant Proteins
ProductCat. No.SourceFusion TagSequence*
SARS-CoV-2 (COVID-19) Omicron Variant (B.1.1.529) Spike RBD Protein21-801, 21-844, 95-128Mammalian Cells/HEK293C-His/C-Fc/His-Avi tagArg319-Phe541 (G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493K/R, G496S, Q498R, N501Y, Y505H.)
SARS-CoV-2 (COVID-19) Omicron Variant (B.1.1.529) Spike S1 Protein95-129, 21-846HEK293/Mammalian CellsHis-Avi tagVal 16 - Arg 685 (A67V, HV69-70del, T95I, G142D, VYY143-145del, N211del, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H)
SARS-CoV-2 (COVID-19) Omicron Variant (B.1.1.529) Spike Trimer Protein21-845Mammalian CellsC-his tagSer13 - Lys1208 (A67V, HV69-70del, T95I, G142D, VYY143-145del, N211del, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F)
Delta

SARS-CoV-2 Delta Variant

Antibodies
ProductCat. No.ApplicationClonalitySpecies
SARS-CoV-2 (COVID-19) Spike 156-157EFdel Antibody (Delta Variant)9689E, WBPolyclonalRabbit
SARS-CoV-2 (COVID-19) Spike L452R Antibody (Delta Variant)9463E, WBPolyclonalRabbit
SARS-CoV-2 (COVID-19) Spike P681R Antibody (Delta Variant)PM-9677, PM-9680EMonoclonalMouse
Recombinant Proteins
ProductCat. No.SourceFusion TagSequence*
SARS-CoV-2 (COVID-19) Delta Variant Spike RBD Protein95-126HEK293His-Avi tagArg319-Phe541 (T478K, L452R)
SARS-CoV-2 (COVID-19) Delta Variant Spike S1 Protein95-127HEK293His-Avi tagVal 16 - Arg 685 (T19R, G142D, EF156-157del, R158G, L452R, T478K, D614G, P681R)
SARS-CoV-2 (COVID-19) Delta Variant Spike RBD Protein21-831Mammalian CellsC-His tagArg319-Phe541 (T478K, L452R)
SARS-CoV-2 (COVID-19) Delta plus Variant (B.1.617.2.1) Spike RBD Protein21-827Mammalian CellsC-His tagArg319-Phe541 (K417N, T478K, L452R)
Gamma

SARS-CoV-2 Gamma Variant

Antibodies
ProductCat. No.ApplicationClonalitySpecies
SARS-CoV-2 (COVID-19) Spike P26S Antibody (Gamma Variant)9573E, WBPolyclonalRabbit
SARS-CoV-2 (COVID-19) Spike 26P AntibodyPM-9583E, WBMonoclonalMouse
SARS-CoV-2 (COVID-19) Spike P26S Antibody (Gamma Variant)PM-9590E, WBMonoclonalMouse
Recombinant Proteins
ProductCat. No.SourceFusion TagSequence*
SARS-CoV-2 (COVID-19) Gamma Variant (P.1) RBD Protein21-810HEK293N-FcArg319-Phe541 (K417T, E484K, N501Y)
SARS-CoV-2 (COVID-19) Gamma Variant (P.1) RBD Protein21-813HEK293C-His tagArg319-Phe541 (K417T, E484K, N501Y)
SARS-CoV-2 (COVID-19) Gamma S RBD RP11-066Mammalian CellsC-His tagE484K, K417T, N501Y
SARS-CoV-2 (COVID-19) Full-Length Gamma Variant (P.1) Spike Protein21-820HEK293C-Rho1D4Met1-Thr1273 (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, T1027I, V1176F)
Alpha

SARS-CoV-2 Alpha Variant

Antibodies
ProductCat. No.ApplicationClonalitySpecies
SARS-CoV-2 (COVID-19) Spike P681H Antibody9359E, WBPolyclonalRabbit
SARS-CoV-2 (COVID-19) Spike P681H AntibodyPM-9371, PM-9373, PM-9374E, WBMonoclonalMouse
SARS-CoV-2 (COVID-19) Spike P681H Antibody (WT)PM-9365, PM-9366, PM-9367E, WBMonoclonalMouse
Recombinant Proteins
ProductCat. No.SourceFusion TagSequence*
SARS-CoV-2 (COVID-19) Alpha Variant (B.1.1.7) Spike RBD Protein21-808HEK293N-FcArg319-Phe541 (N501Y)
SARS-CoV-2 (COVID-19) Alpha Variant (B.1.1.7) Spike RBD Protein21-811HEK293C-His tagArg319-Phe541 (N501Y)
SARS-CoV-2 (COVID-19) Alpha S RBD RP11-064Mammalian CellsC-His tagN501Y
SARS-CoV-2 (COVID-19) Full-Length Alpha Variant (B.1.1.7) Spike Protein21-818HEK293C-Rho1D4Met1-Thr1273 (del 69, del 70, del 144, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H)
Controls
ProductCat. No.ApplicationClonalitySpecies
SARS-CoV-2 (COVID-19) Spike 156-157EF Antibody9685E, WBPolyclonalRabbit
SARS-CoV-2 (COVID-19) Spike 681P Antibody (WT) 9091E, WBPolyclonalRabbit
SARS-CoV-2 (COVID-19) Spike S1 Antibody9083E, IF, IHC, WBPolyclonalRabbit
SARS-CoV-2 (COVID-19) Spike 26P Antibody [1C3H9]PM-9583EMonoclonalMouse
Other SARS-CoV-2 Variants Recombinant Proteins
ProductCat. No.SourceFusion TagSequence*
SARS-CoV-2 (COVID-19) Beta Variant (B.1.351) Spike RBD Protein21-809HEK293N-FcArg319-Phe541 (K417N, E484K, N501Y)
SARS-CoV-2 (COVID-19) Beta Variant (B.1.351) Spike RBD Protein21-812HEK293C-HisArg319-Phe541 (K417N, E484K, N501Y)
SARS-CoV-2 (COVID-19) Beta S RBD RP11-065Mammalian CellsC-HisK417N, E484K, N501Y
SARS-CoV-2 (COVID-19) Alpha/Beta Spike Trimer11-067Mammalian CellsC-HisE484K
SARS-CoV-2 (COVID-19) Epsilon Variant (B.1.429) Spike RBD Protein20-180Mammalian CellsC-HisArg319-Phe541 (L452R)
SARS-CoV-2 (COVID-19) Variant (B.1.160) Spike RBD (S477N) Protein20-181Mammalian CellsC-HisArg319-Phe541 (S477N)
SARS-CoV-2 (COVID-19) Kappa Variant (B.1.617) Spike RBD Protein20-185Mammalian CellsC-HisArg319-Phe541 (E484Q, L452R)
SARS-CoV-2 (COVID-19) Lambda Variant (B.1.1.1) Spike RBD Protein21-828Mammalian CellsC-HisArg319-Phe541 (L452Q, F490S)
SARS-CoV-2 (COVID-19) Variant Spike RBD (E484D) Protein21-829Mammalian CellsArg319-Phe541 (E484D)
SARS-CoV-2 (COVID-19) Mu Variant (B.1.621) Spike RBD Protein21-830Mammalian CellsArg319-Phe541 (R346K, E484K, N501Y, D614G, P681H)
SARS-CoV-2 (COVID-19) Full-Length Beta Variant (B.1.351) Spike Protein21-819HEK293C-Rho1D4Met1-Thr1273 (del 144, K417N, E484K, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H)
SARS-CoV-2 (COVID-19) Full-Length Eta Variant (B.1.525) Spike Protein21-821HEK293C-Rho1D4Met1-Thr1273 (del 69-70, del 144, Q52R, E484K, Q677H, F888L)
SARS-CoV-2 (COVID-19) Full-Length Epsilon Variant (B.1.429) Spike Protein21-822HEK293C-Rho1D4Met1-Thr1273 (S13I, W152C, L452R, D1183Y)
SARS-CoV-2 (COVID-19) Full-Length Kappa Variant (B.1.617.1) Spike Protein21-823HEK293C-Rho1D4Met1-Thr1273 (G142D, E154K, L452R, E484Q, D614G, P681R, Q1071H)

References

  • Duchene, Sebastian, Leo Featherstone, Melina Haritopoulou-Sinanidou, Andrew Rambaut, Philippe Lemey, and Guy Baele. 2020. “Temporal Signal and the Phylodynamic Threshold of SARS-CoV-2.” Virus Evolution 6 (2): veaa061.
  • Gamage, Akshamal M., Kai Sen Tan, Wharton O. Y. Chan, Jing Liu, Chee Wah Tan, Yew Kwang Ong, Mark Thong, et al. 2020. “Infection of Human Nasal Epithelial Cells with SARS-CoV-2 and a 382-Nt Deletion Isolate Lacking ORF8 Reveals Similar Viral Kinetics and Host Transcriptional Profiles.” PLoS Pathogens 16 (12): e1009130.
  • Gu, Hongjing, Qi Chen, Guan Yang, Lei He, Hang Fan, Yong-Qiang Deng, Yanxiao Wang, et al. 2020. “Adaptation of SARS-CoV-2 in BALB/c Mice for Testing Vaccine Efficacy.” Science 369 (6511): 1603–7.
  • Hoffmann, Markus, Hannah Kleine-Weber, and Stefan Pöhlmann. 2020. “A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells.” Molecular Cell 78 (4): 779–84.e5.
  • Kemp, S. A., D. A. Collier, R. Datir, S. Gayed, A. Jahun, M. Hosmillo, Iatm Ferreira, et al. 2020. “Neutralising Antibodies Drive Spike Mediated SARS-CoV-2 Evasion.” Infectious Diseases (except HIV/AIDS). medRxiv. https://doi.org/10.1101/2020.12.05.20241927.
  • McCarthy, Kevin R., Linda J. Rennick, Sham Nambulli, Lindsey R. Robinson-McCarthy, William G. Bain, Ghady Haidar, and W. Paul Duprex. 2020. “Natural Deletions in the SARS-CoV-2 Spike Glycoprotein Drive Antibody Escape.” Microbiology. bioRxiv.
  • Peacock, Thomas P., Daniel H. Goldhill, Jie Zhou, Laury Baillon, Rebecca Frise, Olivia C. Swann, Ruthiran Kugathasan, et al. 2020. “The Furin Cleavage Site of SARS-CoV-2 Spike Protein Is a Key Determinant for Transmission due to Enhanced Replication in Airway Cells.” Cold Spring Harbor Laboratory. https://doi.org/10.1101/2020.09.30.318311.
  • Starr, Tyler N., Allison J. Greaney, Sarah K. Hilton, Daniel Ellis, Katharine H. D. Crawford, Adam S. Dingens, Mary Jane Navarro, et al. 2020. “Deep Mutational Scanning of SARS-CoV-2 Receptor Binding Domain Reveals Constraints on Folding and ACE2 Binding.” Cell 182 (5): 1295–1310.e20.
  • Zhu, Yunkai, Fei Feng, Gaowei Hu, Yuyan Wang, Yin Yu, Yuanfei Zhu, Wei Xu, et al. 2020. “The S1/S2 Boundary of SARS-CoV-2 Spike Protein Modulates Cell Entry Pathways and Transmission.” Cold Spring Harbor Laboratory. https://doi.org/10.1101/2020.08.25.266775.

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