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SARS-CoV-2 Spike Reagents

The Spike Protein (S)

Coronavirus invades cells through spike (S) glycoproteins, a class I fusion protein. It is the major viral surface protein that coronavirus uses to bind to the human cell surface receptor. The S protein also mediates the fusion of the host and viral cell membranes. This allows the virus to enter human cells and begin infection (1).

The spike protein is the major target for neutralizing antibodies and vaccine development (2). The protein modeling suggests that there is a strong interaction between the spike protein receptor-binding domain and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulates both the cross-species and human-to-human transmissions of COVID-19 (3). A recent study has shown that the SARS-CoV-2 spike protein binds ACE2 with a higher affinity than SARS-CoV spike protein (4).

The spike protein in SARS-CoV-2 is heavily glycosylated. Therefore, it utilizes an N-terminal signal sequence to gain access to the ER, and mediate attachment to host receptors. It is the largest structure and makes distinct spikes on the surface of the virus.

For SARS-CoV-2, S protein is cleaved by cellular furin-like protease TMPRSS2 into two separate polypeptides S1 and S2. S1 also consists of a receptor-binding domain (RBD) which binds to the virus ACE2 receptor.

SARS-CoV-2 Spike Reagents

ProSci offers a catalog of SARS-CoV-2 spike reagents! This includes antibodies and recombinant proteins for the S1 and S2 subregions of the spike protein, the spike receptor-binding domain, and more.

ProSci has also developed a catalog of spike S1 single domain antibodies. These reagents can benefit your research due to their ability to target unique epitopes inaccessible by conventional antibodies!

Here are other reagents that ProSci also provides:

  • Spike receptor-binding domain (RBD)
  • The extracellular domain (ECD)
  • IgM and IgA antibodies against spike
  • Spike cleavage site antibodies and recombinant proteins

Spike Variant Antibodies and Recombinant Proteins

To enable a proteomic analysis of SARS-CoV-2 protein expression, ProSci R&D has created SARS-CoV-2 point mutation-specific antibodies, for Omicron, Delta, Gamma, and Alpha variants. ProSci further offers Omicron variant recombinant proteins, including Spike Trimer, Spike S1, and RBD proteins with His-Avi tag, and Nucleocapsid protein.

Explore the Complete Set of SARS-CoV-2 Variants Research Reagents

Spike S1

The S1 subregion of the spike protein recognizes and binds to the angiotensin-converting enzyme 2 (ACE2) receptors on the host cell. Here are antibodies and recombinant proteins ProSci provides against the S1 subregion:

Antibodies

ProductCat. No.ApplicationClonalitySpecies
SARS-CoV-2 (COVID-19) Spike S1 Antibody9083ELISA, IHC, WB, IFPolyclonalRabbit
SARS-CoV-2 (COVID-19) Spike S1 Antibody (cleavage site)9091ELISA, WB, IFPolyclonalRabbit
SARS-CoV-2 (COVID-19) Spike S1 Antibody [SP422]10-350ELISAMonoclonalRabbit
SARS-CoV-2 (COVID-19) Spike S1 Antibody [SP185]10-351ELISAMonoclonalRabbit
Recombinant SARS-CoV-2 (COVID-19) (S1) -2 Antibody [CR3022]10-703ELISAMonoclonalMouse
Recombinant SARS-CoV-2 (COVID-19) (S1) -1 Antibody [CR3022]10-706ELISAMonoclonalHuman
Recombinant SARS-CoV-2 (COVID-19) (S1) -3 Antibody [H4]10-707ELISAMonoclonalHuman
Recombinant SARS-CoV-2 (COVID-19) (S1) -4 Antibody [B38]10-708ELISAMonoclonalHuman
Recombinant SARS-CoV-2 (S1) -1 Neutralizing antibody Antibody10-711ELISAMonoclonalHuman
Recombinant SARS-CoV-2(S1)-6 Antibody10-712ELISAMonoclonalHuman
Recombinant SARS-CoV-2 S-NTD Antibody10-717ELISAMonoclonalHuman
SARS-CoV-2 (COVID-19) S-hIgG1 Neutralizing Antibody [8A5]93-304ELISA, NeutMonoclonalHuman
SARS-CoV-2 (COVID-19) S-mIgG1 Neutralizing Antibody [8A5]93-305ELISA, NeutMonoclonalMouse
SARS-CoV-2 (COVID-19) S-cIgG1 Neutralizing Antibody [8A5]93-306ELISA, NeutMonoclonalMonkey
SARS-CoV-2 (COVID-19) S Antibody [2B7]93-310ELISAMonoclonalHuman
SARS-CoV-2 (COVID-19) S1 Antibody [5D9]93-311ELISAMonoclonalHuman

Recombinant Proteins

ProductCat. No.SourceFusion TagSequence
SARS-CoV-2 (COVID-19) S1 Protein Recombinant Protein (D614G)92-746Human CellsC-10 His TagGln14 - Arg685 (D614G)
SARS-CoV-2 S1 Recombinant Protein10-076HEK293 CellsTag FreeVal16 - Arg685
SARS-CoV-2 (COVID-19) Spike S1 Recombinant Protein10-300HEK293 cellsCT HisVal16 - Arg685
SARS-CoV-2 S1 Recombinant Protein10-428E. coliN-His TagVal16 - Gln677
SARS-CoV-2 (COVID-19) S1 Recombinant Protein10-409HEK293 CellsC-His TagMet16 - Tyr677
SARS-CoV-2 (COVID-19) S1 Recombinant Protein10-422Mammalian CellsC-His TagVal16 - Arg685
SARS-CoV-2 (COVID-19) S1 Recombinant Protein10-423Mammalian CellsC-Fc TagVal16 - Arg685
SARS-CoV-2 (COVID-19) S1 Recombinant Protein97-086HEK293 CellsFcVal16 - Arg685
SARS-CoV-2 (COVID-19) S1 Recombinant Protein97-087HEK293 CellsHis TagVal16 - Arg685
SARS-CoV-2 (COVID-19) Spike S1 Recombinant Protein10-109Human CellsHis-Avi TagGln14 - Arg683
SARS-CoV-2 (COVID-19) Spike S1 Recombinant Protein10-111Human CellsHis TagVal16 - Arg685
SARS-CoV-2 (COVID-19) S1 Recombinant Protein92-727Human CellsC-mFc TagGln14 - Arg685
SARS-CoV-2 (COVID-19) S1 Recombinant Protein92-731Human CellsTag FreeGln14 - Arg685
SARS-CoV-2 (COVID-19) S1 Recombinant Protein10-424Mammalian CellsC-Fc TagSer71 - IIe666
SARS-CoV-2 (COVID-19) Biotinylated Spike S1 Recombinant Protein10-208HEK293 CellsHis-Avi TagGln14 - Arg683
SARS-CoV-2 (COVID-19) S1 CTD Recombinant Protein92-739Human CellsN-8His TagN/A
SARS-COV-2 (COVID-19) Spike Recombinant Protein10-411Mammalian CellsC-Fc TagMet1 - Tyr695

Spike S2

The S2 subregion of the spike protein is the most conserved component. It is responsible for fusing the envelope of the virus with the host cell membrane. Below are antibodies and recombinant proteins ProSci provides against the S2 subregion:

Antibodies

ProductCat. No.ApplicationClonalitySpecies
SARS-CoV-2 (COVID-19) Spike S2 Antibody3525ELISA, WB, IFPolyclonalRabbit
SARS-CoV-2 (COVID-19) Spike Antibody (biotin)3525-biotin ELISAPolyclonalRabbit
SARS-CoV-2 (COVID-19) Spike S2 Antibody9119ELISA, WB, IFPolyclonalRabbit
SARS-CoV-2 (COVID-19) Spike S2 Antibody9123ELISA, WB, IFPolyclonalRabbit
SARS-CoV-2 (COVID-19) Spike S2 Antibody [4F10]PM-9428 ELISA, WB, IF, IHC-P MonoclonalMouse
SARS-CoV-2 (COVID-19) Spike S2 Antibody [5E6]PM-9429 ELISA, WB, IF, IHC-PMonoclonalMouse
SARS-CoV-2 (COVID-19) Spike S2 [P1A6]SD9785ELISAMonoclonalLlama
SARS-CoV-2 (COVID-19) Spike S2 [P1B8]SD9787ELISAMonoclonalLlama
SARS-CoV-2 (COVID-19) Spike S2 [P1G5]SD9789ELISAMonoclonalLlama
SARS-CoV-2 (COVID-19) Spike S2 [P1A9]SD9791ELISAMonoclonalLlama

Recombinant Proteins

ProductCat. No.SourceFusion TagSequence
SARS-CoV-2 (COVID-19) S2 Recombinant Protein10-426E. coliN-His TagSer686 - Pro1213
SARS-CoV-2 (COVID-19) Spike S2 ECD Recombinant Protein10-115BaculovirusC-His TagSer686 - Pro1213

Spike S1 Single Domain Antibodies

Single domain antibodies (sdAbs) are able to target unique epitopes inaccessible by conventional antibodies. Explore the many benefits of sdAbs.

ProductCloneCat. No.ApplicationClonalitySpecies
SARS-CoV-2 (COVID-19) S1 RBD sdAb[T4P3-B5]SD9431ELISAMonoclonalLlama
SARS-CoV-2 (COVID-19) S1 RBD sdAb[T4P3-B7]SD9433ELISAMonoclonalLlama
SARS-CoV-2 (COVID-19) S1 RBD sdAb[RBD-2B9]SD9437ELISA, ICCMonoclonalLlama
SARS-CoV-2 (COVID-19) S1 RBD sdAb[TSP4-A12]SD9439ELISA, ICCMonoclonalLlama
SARS-CoV-2 (COVID-19) S1 RBD sdAb[T5P7-G10]SD9441ELISA, ICCMonoclonalLlama
SARS-CoV-2 (COVID-19) Spike RBD sdAb[T5P8-F9]SD9503ELISAMonoclonalLlama
SARS-CoV-2 (COVID-19) Spike RBD sdAb[T5P7-G12]SD9505ELISAMonoclonalLlama
SARS-CoV-2 (COVID-19) S1 RBD sdAb[T4P5-H12]SD9507ELISA, ICCMonoclonalLlama
SARS-CoV-2 (COVID-19) S1 RBD sdAb[T3P1-C8]SD9511ELISA, ICCMonoclonalLlama

Spike Receptor-binding Domain (RBD)

Antibodies

ProductCat. No.ApplicationClonalitySpecies
SARS-CoV-2 (COVID-19) Spike RBD Antibody9087ELISA, WB, IFPolyclonalRabbit
SARS-CoV-2 (COVID-19) S Antibody [5E8]93-309ELISAMonoclonalHuman
Recombinant SARS-CoV-2 RBD antibody10-713ELISAMonoclonalHuman
Recombinant SARS-CoV-2 RBD Antibody10-715ELISAMonoclonalHuman
Recombinant SARS-CoV-2 RBD Antibody10-718ELISAMonoclonalHuman
SARS-CoV-2 Spike RBD Antibody [2165]10-052ELISAMonoclonalHuman
SARS-CoV-2 Spike RBD Antibody [2165] (Biotin)10-053ELISAMonoclonalHuman
SARS-CoV-2 Spike RBD Antibody [2165] (HRP)10-054ELISAMonoclonalHuman
SARS-CoV-2 Spike RBD Antibody [2838]10-058ELISAMonoclonalHuman
SARS-CoV-2 Spike RBD Antibody [2381]10-059ELISAMonoclonalHuman
SARS-CoV-2 Spike RBD Antibody [2355]10-060ELISAMonoclonalHuman
SARS-CoV-2 Spike RBD Antibody [2196] (Biotin)10-062ELISAMonoclonalHuman
SARS-CoV-2 Spike RBD Antibody [2196] (HRP)10-063ELISAMonoclonalHuman
SARS-CoV-2 Spike RBD Antibody [2196]10-064ELISAMonoclonalHuman

Recombinant Proteins

ProductCat. No.SourceFusion TagSequence
SARS-CoV-2 Spike Protein RBD Domain RP20-232BacteriaN-Term MBP Uncleaved319 - 541
SARS-CoV-2 Spike Protein RBD Domain RP20-233BacteriaN-Term MBP Uncleaved1 - 1273

Spike Extracellular Domain (ECD)

Antibodies

ProductCat. No.ApplicationClonalitySpecies
SARS-CoV-2 (COVID-19) Spike Antibody24-032ELISA, WBMonoclonalRabbit
SARS-CoV-2 (COVID-19) Spike ECD Antibody10-528ELISA, WBPolyclonalRabbit
SARS-CoV-2 (COVID-19) Spike ECD Antibody10-534ELISA, WBPolyclonalRabbit

Recombinant Proteins

ProductCat. No.SourceFusion TagSequence
SARS-CoV-2 Trimeric Spike (S) Recombinant Protein10-075HEK293 CellsTag FreeGln14 - Gln1208
SARS-CoV-2 S-Trimer Protein Recombinant Protein (D614G)92-748Human CellsC-6His TagCys15 - Gln1208 (D614G)
SARS-CoV-2 (COVID-19) S1+S2 ECD (S-ECD) Recombinant Protein10-108Human CellsHis TagVal11 - Gln1208
SARS-CoV-2 (COVID-19) S1+S2 ECD (S-ECD) Recombinant Protein10-121Human CellsHis TagVal11 - Gln1208 (Cleavage Mutation)
SARS-CoV-2 (COVID-19) S1+S2 ECD (S-ECD) Recombinant Protein10-122Human CellsHis TagVal11 - Glu988

IgM & IgA Antibodies

ProductCat. No.ApplicationClonalitySpecies
SARS-CoV-2 (COVID-19) Spike RBD Monoclonal Antibody (IgM)10-571ELISA, NeutrMonoclonalHuman
Recombinant CoV-2/COVID-19 Spike Glycoprotein Antibody IgM10-709ELISA, NeutrMonoclonalHuman
SARS-CoV-2 (COVID-19) S-IgM Neutralizing Antibody [8A5]93-307ELISA, NeutrMonoclonalHuman
SARS-CoV-2 (COVID-19) S-IgA Neutralizing Antibody [8A5]93-308ELISA, NeutrMonoclonalHuman

Spike Cleavage Site Antibodies

ProductCat. No.ApplicationClonalitySpecies
SARS-CoV-2 (COVID-19) Spike S1 Antibody (cleavage site)9091ELISA, WB, IFPolyclonalRabbit
SARS-CoV-2 (COVID-19) Spike Antibody (cleavage site)9095ELISA, WB, IFPolyclonalRabbit

Spike Recombinant Proteins (D614G)

ProductCat. No.SourceFusion TagSequence
SARS-CoV-2 (COVID-19) S-Trimer Protein Recombinant Protein (D614G)92-748Human CellsC-6 His TagCys15 - Gln1208 (D614G)
SARS-CoV-2 (COVID-19) S1 Protein Recombinant Protein (D614G)92-746Human CellsC-10 His TagGln14 - Arg685 (D614G)

Spike-trimer Recombinant Proteins

ProductCat. No.SourceFusion TagSequence
SARS-CoV-2 Trimeric Spike (S) Recombinant Protein10-075HEK293 CellsTag FreeGln14 - Gln1208
SARS-CoV-2 (COVID-19) S-Trimer Protein Recombinant Protein (D614G)92-748Human CellsC-6 His TagCys15 - Gln1208 (D614G)

Spike N-terminal Domain (NTD)

Antibodies

ProductCat. No.ApplicationClonalitySpecies
SARS-CoV-2 Spike NTD Antibody [2215]10-061ELISAMonoclonalHuman
SARS-CoV-2 Spike NTD Antibody [2146]10-055ELISAMonoclonalHuman
SARS-CoV-2 Spike NTD Antibody [2146] (Biotin)10-056ELISAMonoclonalHuman
SARS-CoV-2 Spike NTD Antibody [2146] (HRP)10-057ELISAMonoclonalHuman

Recombinant Proteins

ProductCat. No.SourceFusion TagSequence
SARS-COV-2 NTD Recombinant Protein10-079HEK293 CellsTag FreeVal16 - Ser306
SARS-COV-2 (COVID-19) S Protein NTD Recombinant Protein92-738Human CellsC-6His TagGln14 - Asp290
SARS-COV-2 (COVID-19) S Protein HR1 Recombinant Protein92-760E. coliN-6His - Sumo TagGly910 - Glu988
SARS-COV-2 (COVID-19) S Protein HR1 Recombinant Protein92-761E. coliTag FreeGly910 - Glu988

Neutralizing Antibodies

These antibodies bind to spike RBD and binding to the ACE2 receptor:

ProductCat. No.ApplicationClonalitySpecies
SARS-CoV-2 (COVID-19) S-hIgG1 Neutralizing Antibody [8A5]93-304ELISA, NeutrMonoclonalHuman
SARS-CoV-2 (COVID-19) S-mIgG1 Neutralizing Antibody [8A5]93-305ELISA, NeutrMonoclonalMouse
SARS-CoV-2 (COVID-19) S-cIgG1 Neutralizing Antibody [8A5]93-306ELISA, NeutrMonoclonalMonkey
SARS-CoV-2 (COVID-19) S-IgM Neutralizing Antibody [8A5]93-307ELISA, NeutrMonoclonalHuman
SARS-CoV-2 (COVID-19) S-IgA Neutralizing Antibody [8A5]93-308ELISA, NeutrMonoclonalHuman
SARS-CoV-2 Spike RBD Antibody [2165]10-052ELISA, NeutrMonoclonalHuman
SARS-CoV-2 (COVID-19) Spike S1 Antibody [SP422]10-350ELISA, NeutrMonoclonalRabbit
SARS-CoV-2 (COVID-19) Spike S1 Antibody [SP185]10-351ELISA, NeutrMonoclonalRabbit
Recombinant SARS-CoV-2 (COVID-19) (S1) -1 Antibody [CR3022]10-706ELISA, NeutrMonoclonalHuman
Recombinant SARS-CoV-2 (COVID-19) (S1) -3 Antibody [H4]10-707ELISA, NeutrMonoclonalHuman
Recombinant SARS-CoV-2 (S1) -1 Neutralizing antibody Antibody10-711ELISA, NeutrMonoclonalHuman
Recombinant SARS-CoV-2(S1)-6 Antibody10-712ELISA, NeutrMonoclonalHuman
Recombinant SARS-CoV-2 RBD Antibody10-713ELISA, NeutrMonoclonalHuman
Recombinant SARS-CoV-2 RBD Antibody10-715ELISA, NeutrMonoclonalHuman
Recombinant SARS-CoV-2 S-NTD Antibody10-717ELISA, NeutrMonoclonalHuman
Recombinant SARS-CoV-2 RBD antibody10-718ELISA, NeutrMonoclonalHuman

Humanized Antibodies

ProductCat. No.ApplicationClonalityProtein Structure
SARS-CoV-2 (COVID-19) Spike RBD Monoclonal Antibody10-551, 10-552, 10-555, 10-556, 10-559, 10-560ELISA, Neut, WBMonoclonalS-RBD protein
SARS-CoV-2 (COVID-19) Spike RBD Monoclonal Antibody (Biotin)10-553, 10-557, 10-561ELISA, Neut, WBMonoclonalS-RBD protein
SARS-CoV-2 (COVID-19) Spike RBD Monoclonal Antibody (HRP)10-554, 10-558, 10-562ELISA, Neut, WBMonoclonalS-RBD protein
SARS-CoV-2 (COVID-19) Spike-ECD Monoclonal Antibody10-563, 10-564, 10-567, 10-568ELISA, Neut, WBMonoclonalS-ECD protein
SARS-CoV-2 (COVID-19) Spike-ECD Monoclonal Antibody (Biotin)10-565, 10-569ELISA, Neut, WBMonoclonalS-ECD protein
SARS-CoV-2 (COVID-19) Spike-ECD Monoclonal Antibody (HRP)10-566, 10-570ELISA, Neut, WBMonoclonalS-ECD protein

References

  • Cuffari, B. (2021, February 24). What are Spike Proteins? News. https://www.news-medical.net/health/What-are-Spike-Proteins.aspx.
  • (1) Belouzard et al. Viruses. 2012;4(6):1011-33.
  • (2) Lee et al. J Virol. 2006;80(8):4079-87.
  • (3) Wan et al. J Virol. 2020.
  • (4) Wrapp et al. Science. 2020.

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