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Human Coronavirus Research Reagents

Human coronaviruses (HCoVs), including HCoV-229E, HCoV-OC43, HCoV-NL63, and HCoV-HKU1, are traditionally known to cause symptoms of the common cold with only moderate clinical impact. Although it is speculated that the spillover of OC43 as a bovine CoV to humans, caused the 1890 flu pandemic and not Influenza Virus (1). Both HCoV-OC43 and HCoV-HKU1 originated in rats. Whereas while SARS-CoV-2 and HCoV-NL63 appear to have originated in bats, their zoonotic intermediate, is not yet known. It is of interest to note that SADS-CoV (swine acute diarrhea syndrome coronavirus) also originated in bats but as so far known has not crossed to humans. Coronaviruses can cause colds with major symptoms, such as fever, and a sore throat from swollen adenoids. Coronaviruses can cause pneumonia (either direct viral pneumonia or secondary bacterial pneumonia) and bronchitis (either direct viral bronchitis or secondary bacterial bronchitis).

Human-Coronaviruses Research

ProSci offers recombinant proteins against the Human-Coronaviruses. Explore our list of reagents below

ProductCat. No.SourceFusion TagSequence
HCoV-229E Nucleocapsid Recombinant Protein11-163E. coliHis TagMet1-Asn389
HCoV-HKU1 (isolate N5) S1 Recombinant Protein11-195HEK293 CellsHis TagAla13-Arg756
HCoV-229E S1 Recombinant Protein11-196HEK293 CellsHis TagCys16-Ala536
HCoV-NL63 S1 Recombinant Protein11-197HEK293 CellsHis TagCys19-Val717
Human CoV 229E Nucleocapsid Protein RP20-201BacteriaN-Term MBP Uncleaved1 - 389
Human CoV 229E Nucleocapsid Protein RP20-228BacteriaN-Term GST Uncleaved1 - 389
Human CoV OC43 Nucleocapsid Protein RP20-227BacteriaN-Term GST Uncleaved1 - 389
Human CoV OC43 Nucleocapsid Protein RP20-202BacteriaN-Term MBP Uncleaved1 - 389

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