Vaccinia Virus B18R Recombinant Protein Cat. No.: 97-072

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psi-iconSpecifications
SPECIES:Vaccinia Virus
SOURCE SPECIES:HEK293 cells
SEQUENCE:His 20 - Glu 351
FUSION TAG:His Tag
TESTED APPLICATIONS:WB
APPLICATIONS:This recombinant protein can be used for WB. For research use only.
psi-iconProperties
PURITY:>95% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.
PREDICTED MOLECULAR WEIGHT:40.3 kDa
PHYSICAL STATE:Lyophilized
BUFFER:PBS, pH7.4
STORAGE CONDITIONS:Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:B18R
ACCESSION NO.:P25213
OFFICIAL SYMBOL:B18R
GENE ID:3707577
psi-iconBackground and References
BACKGROUND:B18R is a type I interferon (IFN)-binding protein and it is encoded by the B18R open reading frame in the WR (Western Reserve) strain of vaccinia virus, which contains two Ig-like C2-type domains and one Ig-like V-type domain. B18R exists in a soluble and a membrane-bound form. As a type I IFN receptor, B18R counteracts the antiviral effects of host IFN-alpha/beta. Also, B18R acts as a soluble IFN-alpha receptor and thus inhibits the interaction between host IFN-alpha and its receptor.
REFERENCES:1) Alcami A., et al., 2000, J. Virol. 74:11230-11239.
2) Waibler Z., et al., 2009, J. Virol. 83:1563-1571.

FOR RESEARCH USE ONLY.

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