TRAIL-R2 Antibody [HS201] (biotin) Cat. No.: 36-130

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psi-iconSpecifications
HOST SPECIES:Mouse
SPECIES REACTIVITY: Human
IMMUNOGEN: Recombinant human TRAIL-R2 (DR5).
TESTED APPLICATIONS: Flow, Func, ICC, IHC, IP
APPLICATIONS: Functional Application: Inhibition (blocks TRAIL-R2 mediated killing if applied in solution). Immunohistochemistry: (paraffin sections, 15ug/ml).
SPECIFICITY: Recognizes human TRAIL-R2. Does not cross-react with human TRAIL-R1, -R3 or -R4.

psi-iconProperties
PURIFICATION:>95% (SDS-PAGE)
CLONALITY:Monoclonal
ISOTYPE:IgG1
CONJUGATE:Biotin
PHYSICAL STATE:Liquid
BUFFER:Liquid. In PBS containing 0.02% sodium azide.
CONCENTRATION:0.5 mg/ml
STORAGE CONDITIONS:Stable for at least 1 year after receipt when stored at -20˚C.

psi-iconAdditional Info
OFFICIAL SYMBOL:TNFRSF10B
ALTERNATE NAMES:TRAIL Receptor 2; DR5; KILLER; TNFRSF10B; CD262
ACCESSION NO.:2338419
PROTEIN GI NO.:AF012535
GENE ID:8795
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:TRAIL-R2 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.

ANTIBODIES FOR RESEARCH USE ONLY.

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