TNF-Alpha Antibody [MAb11] Cat. No.: 77-180

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psi-iconSpecifications
HOST SPECIES:Mouse
SPECIES REACTIVITY: Human
TESTED APPLICATIONS: Flow, IHC
SPECIFICITY: The MAb11 monoclonal antibody specifically reacts with human tumor necrosis factor alpha (TNF-alpha), a 157 amino acid non-glycosylated protein.

psi-iconProperties
PURIFICATION:The monoclonal antibody was purified utilizing affinity chromatography.
CLONALITY:Monoclonal
ISOTYPE:Mouse IgG1, kappa
CONJUGATE:Unconjugated
PHYSICAL STATE:liquid
BUFFER:Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
CONCENTRATION:batch dependent
STORAGE CONDITIONS:The product should be stored undiluted at 4˚C . Do not freeze.

psi-iconAdditional Info
OFFICIAL SYMBOL:TNF
ALTERNATE NAMES:DIF, TNFA, TNFSF2, TNF-alpha, TNF
GENE ID:7124
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:The MAb11 monoclonal antibody specifically reacts with human tumor necrosis factor alpha (TNF-alpha), a 157 amino acid non-glycosylated protein. TNF-alpha is a pleiotropic pro-inflammatory cytokine secreted by various cells including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands and signals through two receptors, TNFR1 and TNFR2. TNF-alpha is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-alpha also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes. The MAB11 antibody was generated from recombinant human TNF and is reported to be a neutralizing antibody.

ANTIBODIES FOR RESEARCH USE ONLY.

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