TMEM192 Antibody Cat. No.: 6227

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human, Mouse, Rat
IMMUNOGEN: TMEM192 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human TMEM192.

The immunogen is located within amino acids 180 - 230 of TMEM192.
TESTED APPLICATIONS: ELISA, IF, IHC-P, WB
APPLICATIONS: TMEM192 antibody can be used for detection of TMEM192 by Western blot at 0.5 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
SPECIFICITY: At least two isoforms of TMEM192 are known to exist; this antibody will recognize both. TMEM192 antibody is predicted to not cross-react with other TMEM proteins.
POSITIVE CONTROL:1) Cat. No. 1220 - SK-N-SH Cell Lysate

psi-iconProperties
PURIFICATION:TMEM192 Antibody is affinity chromatography purified via peptide column.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:TMEM192 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:TMEM192 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

psi-iconAdditional Info
OFFICIAL SYMBOL:TMEM192
ALTERNATE NAMES:TMEM192 Antibody: Transmembrane protein 192
ACCESSION NO.:NP_001093859
PROTEIN GI NO.:154240704
GENE ID:201931
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:TMEM192 Antibody: TMEM192 is a widely expressed, four transmembrane protein that localizes to late endosomal/lysosomal membranes. This localization is mediated by two dileucine motifs present at the amino-terminus of TMEM192. A cysteine residue near the carboxy residue is responsible for disulfide bond formation in TMEM192 homodimers. Little is known about the function of this protein.
REFERENCES:1) Schroder B, Wrocklage C, Hasilik A, et al. Molecular characterisation of ‘transmembrane protein 192'(TMEM192, a novel protein of the lysosomal membrane. Biol. Chem. 2010; 391:695-704.
2) Zhu H, Liang Z, and Li G. Rabex-5 is a Rab22 effector and mediates a Rab22-Rab5 signaling cascade in endocytosis. Mol. Biol. Cell 2009; 20:4720-9.

ANTIBODIES FOR RESEARCH USE ONLY.

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