TIM-3 Detection Set (Risk Free) Cat. No.: RF16100

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psi-iconSpecifications
SPECIES REACTIVITY:Human
TESTED APPLICATIONS:ELISA, Flow, ICC, IF, IHC-P, WB
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
IMMUNOGEN:TIM-3 antibody was raised against the extracellular domain of human TIM-3
HOST SPECIES:Mouse
psi-iconSet Contents
Catalog Number RF16103Catalog number RF16103 — TIM3 Antibody [10C10]
Catalog Number RF16104Catalog number RF16104 — TIM3 Antibody [1H4]
Catalog Number RF16105Catalog number RF16105 — TIM3 Antibody [3G7]
Catalog Number RF16106Catalog number RF16106 — TIM3 Antibody [2A6]
Catalog Number RF16107Catalog number RF16107 — TIM3 Antibody [1B10]
Catalog Number RF16108Catalog number RF16108 — TIM3 Antibody [1C6]
Catalog Number RF16109Catalog number RF16109 — TIM3 Antibody [9G1]
psi-iconProperties
PHYSICAL STATE:Liquid
BUFFER:PBS containing 0.02% sodium azide.
CONCENTRATION:Antibody 1 mg/mL
STORAGE CONDITIONS:Antibodies can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Monoclonal
ISOTYPE:IgG1, IgG2b
CONJUGATE:Unconjugated
psi-iconAdditional Info
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground
BACKGROUND:The immune checkpoint protein TIM3 is a member of the immunoglobulin superfamily and TIM family of proteins that was initially identified as a specific marker of fully differentiated IFN-γ producing CD4 T helper 1 (Th1) and CD8 cytotoxic cells. It is a Th1-specific cell surface protein that regulates macrophage activation and negatively regulates Th1-mediated auto- and alloimmune responses, and is also highly expressed on regulatory T cells, monocytes, macrophages, and dendritic cells (1). TIM3 and PD-1 are co-expressed on most CD4 and CD8 T cells infiltrating solid tumors or in hematologic malignancy in mice; blocking TIM3 in conjugation with a PD-1 blockade increases the functionality of exhausted T cells and synergizes with to inhibit tumor growth (2,3). ProSci's Risk-FreeTM antibodies are mouse monoclonal antibodies made to improve in vivo studies. Unlike antibodies developed using proteins made in yeast or bacteria, Risk-FreeTM antibodies are developed with antigens expressed in mammalian cell lines, giving the most native post-translational modifications to the protein. Validated for flow cytometry and ELISA Rigorously tested for the following applications: Immunoblot Immunohistochemistry Immunocytochemistry Immunofluorescence Multiple antibodies per target allowing the user to choose the best antibody for their application Available individually or as a set Risk-FreeTM means they are guaranteed to work for their approved applications

DETECTION-SETS FOR RESEARCH USE ONLY.

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