TIGIT Detection Set Cat. No.: SD8800

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psi-iconSpecifications
SPECIES REACTIVITY:Human
TESTED APPLICATIONS:ELISA, Flow, ICC, IF, IHC
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
IMMUNOGEN:TIGIT antibodies were raised against a recombinant protein corresponding to amino acids 22-141 of human TIGIT.
HOST SPECIES:Llama
psi-iconSet Contents
Catalog Number SD8824Catalog number SD8824 — TIGIT Antibody [2B5]
Catalog Number SD8827Catalog number SD8827 — TIGIT Antibody [2F7]
Catalog Number SD8828Catalog number SD8828 — TIGIT Antibody [2C6]
Catalog Number SD8829Catalog number SD8829 — TIGIT Antibody [2C7]
Catalog Number SD8830Catalog number SD8830 — TIGIT Antibody [2D7]
psi-iconProperties
PHYSICAL STATE:Liquid
BUFFER:TIGIT Antibodies are supplied in PBS.
CONCENTRATION:Antibody 1 mg/mL
STORAGE CONDITIONS:TIGIT antibodies should be stored in working aliquots at -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Monoclonal
ISOTYPE:sdab
CONJUGATE:Unconjugated
psi-iconAdditional Info
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground
BACKGROUND:TIGIT Antibody: The T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. It is expressed on several classes of T cells including follicular B helper T cells (TFH). TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses (1). Similar to other immune checkpoint proteins such as PD-1, TIGIT is upregulated on exhausted T cells in chronic viral infections and cancer. Blockade of both TIGIT and PD-1 pathways leads to tumor rejection in mice suggesting that it may be of therapeutic use against cancer (2).

DETECTION-SETS FOR RESEARCH USE ONLY.

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