TIE2 (phospho Tyr992) Antibody Cat. No.: 79-867

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human, Mouse
IMMUNOGEN: TIE2 (phospho Tyr992) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 992 (E-V-Y (p)-V-K) derived from Human TIE2.
TESTED APPLICATIONS: WB
APPLICATIONS: Western Blot: 1:500~1:1000
SPECIFICITY: The Antibody detects endogenous levels of TIE2 only when phosphorylated at Tyr992.
PREDICTED MOLECULAR WEIGHT: 126 kDa

psi-iconProperties
PURIFICATION:Antibodies were purified by affinity-chromatography using epitope-specific peptide.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:Store antibody at -20˚C for up to one year.

psi-iconAdditional Info
OFFICIAL SYMBOL:TEK
ALTERNATE NAMES:Angiopoietin-1 receptor,EC=2.7.10.1 Tunica interna endothelial cell kinase Tyrosine-protein kinase receptor TEK Tyrosine-protein kinase receptor TIE-2 hTIE2 p140 TEK CD202b TEK TIE2
ACCESSION NO.:NP_000450.2
PROTEIN GI NO.:218511853
GENE ID:7010
psi-iconBackground and References
BACKGROUND:The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.
REFERENCES:1) Schooley K.A., Baum P.R. Oncogene 8:663-670(1993)
2) Dunham I. Nature 429:369-374(2004)
3) Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases

ANTIBODIES FOR RESEARCH USE ONLY.

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