TICRR Antibody Cat. No.: 7857

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human
HOMOLOGY: Predicted species reactivity based on immunogen sequence: Mouse: (74%)
IMMUNOGEN: TICRR antibody was raised against a 19 amino acid peptide near the carboxy terminus of human TICRR.

The immunogen is located within amino acids 1840 - 1890 of TICRR.
TESTED APPLICATIONS: ELISA, IF, IHC-P, WB
APPLICATIONS: TICRR antibody can be used for detection of TICRR by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry at 5 μg/mL. For Immunoflorescence start at 20 μg/mL.

Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
SPECIFICITY: TICRR antibody is human specific. At least two isoforms of TICRR are known to exist.
POSITIVE CONTROL:1) Cat. No. 1308 - Human Small Intestine Tissue Lysate
 2) Cat. No. 11-801 - Human Small Intestine Tissue Slide
PREDICTED MOLECULAR WEIGHT: Predicted: 210 kDa

Observed: 220 kDa

psi-iconProperties
PURIFICATION:TICRR antibody is affinity chromatography purified via peptide column.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:TICRR antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:TICRR antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

psi-iconAdditional Info
OFFICIAL SYMBOL:TICRR
ALTERNATE NAMES:TICRR Antibody: SLD3, Treslin, C15orf42, TopBP1-interacting checkpoint and replication regulator
ACCESSION NO.:NP_689472
PROTEIN GI NO.:118421085
GENE ID:90381
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:TopBP1-interacting checkpoint and replication regulator, Treslin,chromosome 15 open reading frame 42, C15ORF42
REFERENCES:1) Sansam CL, Cruz NM, Danielian PS, et al. A vertebrate gene, ticrr, is an essential checkpoint and replication regulator. Genes Dev. 2010; 24:183-94.
2) Kumagai A, Shevchenko A, Shevchenko A, et al. Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication. J. Cell Biol. 2011;193:995-1007.
3) Kumagai A, Shevchenko A, Shevchenko A, et al. Treslin collaborates with TopBP1 in triggering the initiation of DNA replication. Cell 2010; 140:349-59.
4) Mueller AC, Keaton MA, and Dutta A. DNA replication: mammalian Treslin-TopBP1 interaction mirrors yeast Sld3-Dpb11. Curr. Biol. 2011; 21:R638-40.

ANTIBODIES FOR RESEARCH USE ONLY.

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