| SPECIES: | Human, Mouse |
| SOURCE SPECIES: | Human Cells |
| SEQUENCE: | Ala301-Ser412(Tyr340Phe) |
| FUSION TAG: | Tag Free |
| TESTED APPLICATIONS: | |
| APPLICATIONS: | This recombinant protein can be used for biological assays. For research use only. |
Specifications| PURITY: | Greater than 95% as determined by reducing SDS-PAGE. Endotoxin level less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test. |
| PREDICTED MOLECULAR WEIGHT: | 12.7 kD |
| PHYSICAL STATE: | Lyophilized |
| BUFFER: | Lyophilized from a 0.2 um filtered solution of 4 mM HCl. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O. |
| STORAGE CONDITIONS: | Lyophilized protein should be stored at -20˚C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7˚C for 2-7 days. Aliquots of reconstituted samples are stable at -20˚C for 3 months. |
| ALTERNATE NAMES: | Transforming growth factor beta-3, TGFB3, TGF-beta-3, Latency-associated peptide, LAP |
| ACCESSION NO.: | P10600 |
| OFFICIAL SYMBOL: | TGFB3 |
| GENE ID: | 7043 |
| BACKGROUND: | Transforming growth factor beta 3(TGFB3) is a member of a TGF - beta superfamily which is defined by theirstructural and functional similarities. TGFB3 is secreted as a complex with LAP. This latent form of TGFB3becomes active upon cleavage by plasmin, matrix metalloproteases, thrombospondin -1, and a subset ofintegrins. It binds with high affinity to TGF- beta RII, a type II serine/threonine kinase receptor. TGFB3 is involved incell differentiation, embryogenesis and development.It is believed to regulate molecules involved in cellularadhesion and extracellular matrix (ECM) formation during the process of palate development. Without TGF- beta 3,mammals develop a deformity known as a cleft palate. |
FOR RESEARCH USE ONLY.
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