TFPI Recombinant Protein Cat. No.: 97-069

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psi-iconSpecifications
SPECIES:Rhesus monkey
SOURCE SPECIES:HEK293 cells
SEQUENCE:Asp 29 - Lys 282
FUSION TAG:His Tag
TESTED APPLICATIONS:WB
APPLICATIONS:This recombinant protein can be used for WB. For research use only.
psi-iconProperties
PURITY:>95% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.
PREDICTED MOLECULAR WEIGHT:31.1 kDa
PHYSICAL STATE:Lyophilized
BUFFER:PBS, pH7.4
STORAGE CONDITIONS:Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:TFPI,LACI,TFPI1,EPI,TFI
ACCESSION NO.:Q28864
OFFICIAL SYMBOL:TFPI
GENE ID:613026
psi-iconBackground and References
BACKGROUND:Tissue factor pathway inhibitor (TFPI) is also known as Extrinsic pathway inhibitor (EPI), Lipoprotein - associated coagulation inhibitor (LACI), is a plasma proteinase inhibitor synthesized by vascular endothelial cells and part of it is associated with glycosaminoglycans of these cells. TFPI is a single-chain polypeptide which can reversibly inhibit Factor Xa (Xa) and Thrombin (Factor IIa). TFPI is a secreted protein with a N­terminal acidic region, three Kunitz (K) domains separated with by two linker regions, and a C­terminal basic region. The first K domain inhibits coagulation factor VIIa complexed to tissue factor (TF); The second K domain inhibits factor Xa; The third K domain binds to heparin; The C­terminal basic region may have several functions. For example, it plays an important role in binding of TFPI to cell surfaces.
REFERENCES:1) Bajaj MS., et al., 2001, Thromb Haemost., 86:959.
2) Mine S., et al., 2002, Biochemistry, 41:78.
3) Witt I., et al., 2002, Hamostaseologie, 22:30–35.

FOR RESEARCH USE ONLY.

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