TARBP2 Antibody Cat. No.: 49-320

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Bovine, Chimpanzee, Human, Mouse, Rat, Zebrafish
IMMUNOGEN: A portion of amino acids 150-200 of human TRBP2.
TESTED APPLICATIONS: IHC, WB
APPLICATIONS: TARBP2 antibody can be used in ELISA, Western Blot, immunohistochemistry starting at 5 μg/mL, and immunofluorescence starting at 10 μg/mL.
SPECIFICITY: The amino acid sequence used as immunogen is 100% homologous in human (isoforms a and b), mouse, rat, bovine, chimp, and zebrafish. Human isoform a is a 366 amino acid protein, and human isoform b is a 345 amino acid protein.

psi-iconProperties
PURIFICATION:Immunoaffinity Chromatography
CLONALITY:Polyclonal
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:PBS, 0.2% gelatin, 0.05% sodium azide.
CONCENTRATION:0.5 mg/ml
STORAGE CONDITIONS:Short term: 4˚C. Long term: Store at -20˚C. Avoid freeze-thaw cycles.

psi-iconAdditional Info
OFFICIAL SYMBOL:TARBP2
ALTERNATE NAMES:TARBP2, TAR RNA binding protein 2, TRBP1, TRBP2, TAR RNA-binding protein 2, TRBP, LOQS
ACCESSION NO.:Q15633
PROTEIN GI NO.:209572714
GENE ID:6895
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:Principal Names: TAR (HIV) RNA-binding protein 2; HIV-Transactivating response RNA-binding protein; TRBP; Official Gene Symbol: TARBP2 TRBP belongs to the family of dsRNA-binding proteins. It consists of highly conserved 2 dsRNA-binding domains and C-terminal basic region. It is a unique cellular protein capable of binding to HIV-TAR RNA and stimulates expression of HIV-1 long terminal repeats. It also inhibits the host antiviral and anti-proliferative mechanisms by directly binding to IFN-regulated dsRNA-dependent protein kinase (PKR). TRBP associates with Ago2 protein and forms an integral component of Dicer-containing complex. It has a role in micro RNA processing and in RISC assembly. Other functions of TRBP include promoting cellular growth and tumorigenesis.

ANTIBODIES FOR RESEARCH USE ONLY.

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