Specifications
| HOST SPECIES: | Rabbit |
| SPECIES REACTIVITY: |
Bovine, Chimpanzee, Human, Mouse, Rat, Zebrafish |
| IMMUNOGEN: |
A portion of amino acids 150-200 of human TRBP2. |
| TESTED APPLICATIONS: |
IHC, WB |
| APPLICATIONS: |
TARBP2 antibody can be used in ELISA, Western Blot, immunohistochemistry starting at 5 μg/mL, and immunofluorescence starting at 10 μg/mL. |
| SPECIFICITY: |
The amino acid sequence used as immunogen is 100% homologous in human (isoforms a and b), mouse, rat, bovine, chimp, and zebrafish. Human isoform a is a 366 amino acid protein, and human isoform b is a 345 amino acid protein. |
Properties
| PURIFICATION: | Immunoaffinity Chromatography |
| CLONALITY: | Polyclonal |
| CONJUGATE: | Unconjugated |
| PHYSICAL STATE: | Liquid |
| BUFFER: | PBS, 0.2% gelatin, 0.05% sodium azide. |
| CONCENTRATION: | 0.5 mg/ml |
| STORAGE CONDITIONS: | Short term: 4˚C. Long term: Store at -20˚C. Avoid freeze-thaw cycles. |
Additional Info
| OFFICIAL SYMBOL: | TARBP2 |
| ALTERNATE NAMES: | TARBP2, TAR RNA binding protein 2, TRBP1, TRBP2, TAR RNA-binding protein 2, TRBP, LOQS |
| ACCESSION NO.: | Q15633 |
| PROTEIN GI NO.: | 209572714 |
| GENE ID: | 6895 |
| USER NOTE: | Optimal dilutions for each application to be determined by the researcher. |
Background and References
| BACKGROUND: | Principal Names: TAR (HIV) RNA-binding protein 2; HIV-Transactivating response RNA-binding protein; TRBP; Official Gene Symbol: TARBP2 TRBP belongs to the family of dsRNA-binding proteins. It consists of highly conserved 2 dsRNA-binding domains and C-terminal basic region. It is a unique cellular protein capable of binding to HIV-TAR RNA and stimulates expression of HIV-1 long terminal repeats. It also inhibits the host antiviral and anti-proliferative mechanisms by directly binding to IFN-regulated dsRNA-dependent protein kinase (PKR). TRBP associates with Ago2 protein and forms an integral component of Dicer-containing complex. It has a role in micro RNA processing and in RISC assembly. Other functions of TRBP include promoting cellular growth and tumorigenesis. |
ANTIBODIES FOR RESEARCH USE ONLY.
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