TACI Recombinant Protein Cat. No.: 90-265

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psi-iconSpecifications
SPECIES:Human, Mouse
SOURCE SPECIES:HEK293 cells
SEQUENCE:The extracellular domain of human TACI (aa 2-118) is fused at the C-terminus to the Fc portion of human IgG1.
FUSION TAG:Fc Tag
APPLICATIONS:This recombinant proteins is for research use only.
BIOLOGICAL ACTIVITY: Inhibits BAFF and APRIL activity.
psi-iconProperties
PURITY:>90% (SDS-PAGE).

Endotoxin level is less than 0.01EU/ μg purified protein (LAL test; Lonza).
PHYSICAL STATE:Lyophilized
BUFFER:Contains PBS. Reconstitute with 50 μl sterile water.
CONCENTRATION:1mg/ml after reconstitution.
STORAGE CONDITIONS:Stable for at least 6 months after receipt when stored at -20˚C.
psi-iconAdditional Info
ALTERNATE NAMES:TNFRSF 13B, Tumor Necrosis Factor Receptor Superfamily Member 13B, Transmembrane Activator and CAML interactor, CD267
ACCESSION NO.:O14836
PROTEIN GI NO.:6912694
OFFICIAL SYMBOL:TNFRSF13B
GENE ID:23495
psi-iconBackground and References
BACKGROUND:B-cell activating factor belonging to the TNF family receptor (BAFF-R), B-cell maturation antigen (BCMA), and transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) play critical functions in promoting B-cell survival by engaging the ligands a proliferation-inducing ligand (APRIL) and/or BAFF. TACI is predominantly expressed on peripheral blood B cells and interacts with the B cell activating factor (BAFF) of ligands and a proliferation inducing ligand (APRIL), which are expressed by numerous cell types, including dendritic cells, macrophages and neutrophils. TNFRSF13B, the gene, which encodes TACI is mutated in nearly 10% of patients with common variable immune deficiency (CVID), an antibody deficiency syndrome characterized by loss of memory B cells and plasma cells.

FOR RESEARCH USE ONLY.

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