| HOST SPECIES: | Goat |
| SPECIES REACTIVITY: | Human |
| IMMUNOGEN: | Produced from sera of goats pre-immunized with highly pure (>98%) recombinant hTACI (human TACI). |
| TESTED APPLICATIONS: | ELISA, WB |
| APPLICATIONS: | ELISA: Sandwich: To detect hTACI by sandwich ELISA (using 100 μL/well antibody solution) a concentration of 0.25 - 1.0 μg/mL of this antibody is required. This biotinylated polyclonal antibody, in conjunction with our Polyclonal Anti-Human TACI (XP-5278) as a capture antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hTACI. Western Blot: To detect hTACI by Western Blot analysis this antibody can be used at a concentration of 0.1 - 0.2 μg/mL. Used in conjunction with compatible secondary reagents the detection limit for recombinant hTACI is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions. |
| POSITIVE CONTROL: | 1) Cat. No. 1204 - K562 Cell Lysate |
| 2) Cat. No. 1215 - U937 Cell Lysate |
Specifications| PURIFICATION: | Anti-hTACI specific antibody was purified by affinity chromatography and then biotinylated. |
| CLONALITY: | Polyclonal |
| CONJUGATE: | Biotin |
| PHYSICAL STATE: | Lyophilized |
| STORAGE CONDITIONS: | TACI antibody is stable for at least 2 years from date of receipt at -20˚C. The reconstituted antibody is stable for at least two weeks at 2-8˚C. Frozen aliquots are stable for at least 6 months when stored at -20˚C. Avoid repeated freeze-thaw cycles. |
| OFFICIAL SYMBOL: | TNFRSF13B |
| ALTERNATE NAMES: | CVID, RYZN, TACI, CD267, CVID2, TNFRSF14B |
| ACCESSION NO.: | Q4ACX1 |
| PROTEIN GI NO.: | 121943629 |
| GENE ID: | 23495 |
| USER NOTE: | Centrifuge vial prior to opening. |
| BACKGROUND: | TACI is a lymphocyte specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein binds to both APRIL and BAFF and induces activation of the transcription factors NFAT (nuclear-factor of activated T cells), AP1, and NF kappa B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith Magenis syndrome region on chromosome 17. |
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