STIM-1 Antibody Cat. No.: 39-874

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psi-iconSpecifications
HOST SPECIES:Sheep
SPECIES REACTIVITY: Human
IMMUNOGEN: A synthetic peptide corresponding to a region near the N-terminus.
TESTED APPLICATIONS: ELISA, IHC, WB
APPLICATIONS: ELISA, Western (immuno) blotting, Immunostaining (in testing)

psi-iconProperties
PURIFICATION:Affinity Purified
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid

psi-iconAdditional Info
OFFICIAL SYMBOL:STIM1
ALTERNATE NAMES:Stromal Interaction Molecule 1, GOK, TAM, IMD10, D11S4896E
ACCESSION NO.:EAX02580
PROTEIN GI NO.:209572721
GENE ID:6786
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:STIM-1 is a component of the Ca sensor/channel. It associates with ORAI-1 and form a essential complex involved in store-operated channels. STIM1 activates Ca(2+) influx via Orai1 channels. Expression of STIM and Orai proteins are found in many cell types and knock-out mice lack viability.
REFERENCES:1) Williams RT, Senior PV, Van Stekelenburg L, Layton JE, Smith PJ, Dziadek MA., Stromal interaction molecule 1 (STIM1), a transmembrane protein with growth suppressor activity, contains an extracellular SAM domain modified by N-linked glycosylation., Biochim Biophys Acta. 2002 Apr 1;1596(1):131-137
2) Dziadek MA, Johnstone LS., Biochemical properties and cellular localisation of STIM proteins., Cell Calcium. 2007 Aug;42(2):123-32.
3) Frischauf I, Schindl R, Derler I, Bergsmann J, Fahrner M, Romanin C.,. The STIM/Orai coupling machinery., Channels (Austin). 2008 Jul-Aug;2(4):261-8

ANTIBODIES FOR RESEARCH USE ONLY.

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