Secreted FRP-1 Recombinant Protein Cat. No.: 40-224

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psi-iconSpecifications
SPECIES:Human
SOURCE SPECIES:HeLa cells
SEQUENCE:SEYDYVSFQS DIGPYQSGRF YTKPPQCVDI PADLRLCHNV GYKKMVLPNL LEHETMAEVK QQASSWVPLL NKNCHAGTQV FLCSLFAPVC LDRPIYPCRW LCEAVRDSCE PVMQFFGFYW PEMLKCDKFP EGDVCIAMTP PNATEASKPQ GTTVCPPCDN ELKSEAIIEH LCASEFALRM KIKEVKKENG DKKIVPKKKK PLKLGPIKKK DLKKLVLYLK NGADCPCHQL DNLSHHFLIM GRKVKSQYLL TAIHKWDKKN KEFKNFMKKM KNHECPTFQS VFK
TESTED APPLICATIONS:
BIOLOGICAL ACTIVITY: Biological activity was determined by its ability to inhibit BMP - 2 proliferation effect of ATDC - 5 cells. The expected ED50is 0.3-0.5 μg/mL.
psi-iconProperties
PURITY:Greater than 97% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
PHYSICAL STATE:Lyophilized
STORAGE CONDITIONS:The lyophilized Secreted FRP-1 recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted Secreted FRP-1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing Secreted FRP-1 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
psi-iconAdditional Info
ALTERNATE NAMES:FRP, FRP1, FrzA, FRP-1, SARP2, FRP, Secreted frizzled-related protein 1, Secreted apoptosis-related protein 2
ACCESSION NO.:NP_003003.3
PROTEIN GI NO.:56117838
OFFICIAL SYMBOL:SFRP1
GENE ID:6422
psi-iconBackground and References
BACKGROUND:Secreted Frizzled Related Proteins (sFRPs) modulate WNT signaling by binding directly to WNT proteins in a manner that affects their receptor binding and signaling capabilities. sFRP-1 is a widely distributed protein that can bind directly to WNT1, WNT2, and possibly other WNT proteins, and generally exerts anti-proliferative effects consistent with activity as a WNT antagonist. It also inhibits apoptosis and has been found to be down-regulated in many solid tumors, but up-regulated in uterine leiomyomas. Recombinant human sFRP-1 is a glycosylated 283 amino acid protein containing a cysteine rich Frizzled homologous domain.

FOR RESEARCH USE ONLY.

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