SARS Envelope Antibody Cat. No.: 3533

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Virus
IMMUNOGEN: SARS envelope antibody was raised against a synthetic peptide corresponding to amino acids at the carboxy terminus of the SARS envelope protein.

The immunogen is located within the last 50 amino acids of SARS Envelope.
TESTED APPLICATIONS: ELISA
APPLICATIONS: SARS envelope antibody can be used for the detection of SARS envelope protein in ELISA. It will detect 10 ng of free peptide at 1 μg/mL.

psi-iconProperties
PURIFICATION:SARS Envelope Antibody is affinity chromatography purified via peptide column.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:SARS Envelope Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:SARS Envelope antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

psi-iconAdditional Info
OFFICIAL SYMBOL:E
ALTERNATE NAMES:SARS Envelope Antibody: sM, 4, Envelope small membrane protein, E protein
ACCESSION NO.:P59637
PROTEIN GI NO.:30173401
GENE ID:1489671
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:SARS Envelope Antibody: A novel coronavirus has recently been identified as the causative agent of SARS (Severe Acute Respiratory Syndrome). Coronaviruses are a major cause of upper respiratory diseases in humans. The genomes of these viruses are positive-stranded RNA approximately 27-31kb in length. SARS infection can be mediated by the binding of the viral spike protein, a glycosylated 139 kDa protein and the major surface antigen of the virus, to the angiotensin-converting enzyme 2 (ACE2) on target cells. This binding can be blocked by a soluble form of ACE2.
REFERENCES:1) Marra MA, Jones SJ, Astell CR, et al. The Genome sequence of the SARS-associated corona virus. Science 2003;300:1399-404.
2) Rota PA, Oberste MS, Monroe SS, et al. Characterization of a novel coronavirus associated with severe acute respiratory syndrome. Science 2003;300:1394-9.
3) Navas-Nartin SR and Weiss S. Coronavirus replication and pathogenesis: Implications for the recent outbreak of severe acute respiratory syndrome (SARS), and the challenge for vaccine development. J Neurovirol. 2004;10:75-85.
4) Arbely E, Khattari Z, Brotons G, et al. A highly unusual palindromic transmembrane helical hairpin formed by SARS coronavirus E protein. J Mol. Biol. 2004;3414:769-79.

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