SARS-CoV-2/SARS-CoV Matrix (Membrane) Antibody Cat. No.: 3529

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Virus
HOMOLOGY: Predicted reactivity based on immunogen sequence: SARS-CoV-2 Matrix protein: (identity 80%, homology 93%)
IMMUNOGEN: Anti-SARS-CoV-2/SARS-CoV Matrix antibody (3529) was raised against a peptide corresponding to 15 amino acids near the carboxy-terminus of SARS-CoV Matrix protein.

The immunogen is located within the last 50 amino acids of SARS-CoV Matrix.
TESTED APPLICATIONS: ELISA, WB
APPLICATIONS: WB: 1 μg/mL.

Antibody validated: SARS-CoV-2/SARS-CoV Matrix antibody can be used for the detection of SARS-CoV-2/SARS-CoV Matrix protein in ELISA. It will detect 5 ng of free peptide at 1 μg/mL.

psi-iconProperties
PURIFICATION:SARS-CoV-2/SARS-CoV Matrix Antibody is affinity chromatography purified via peptide column.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:SARS-CoV-2/SARS-CoV Matrix Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:SARS-CoV-2/SARS-CoV Matrix antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

psi-iconAdditional Info
OFFICIAL SYMBOL:M
ALTERNATE NAMES:SARS-CoV-2/SARS-CoV Matrix Antibody: SARS-CoV-2 Matrix protein, SARS Matrix protein, Membrane protein, E1 glycoprotein, M protein
ACCESSION NO.:QHO62114.1
PROTEIN GI NO.:1800455127
GENE ID:43740571
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus. The disease is the cause of the 2019–20 coronavirus outbreak (1). SARS-CoV-2 is the seventh member of the enveloped, positive-stranded RNA viruses that are able to infect humans. The SARS-CoV-2 genome, like other coronaviruses, encodes for multiple structural and nonstructural proteins. The structural proteins include spike protein (S), envelope protein (E), membrane glycoprotein (M), nucleocapsid phosphoprotein (N), and the nonstructural proteins include open reading frame 1ab (ORF1ab), ORF3a, ORF6, ORF7a, ORF8, and ORF10 (2).The membrane (M) protein or matrix protein is the most abundant structural protein and defines the shape of the viral envelope (3). It is an integral membrane protein involved in the budding of the viral particles and interacts with S (Spike) protein. It involves in organization of the nucleoprotein inside, which includes many copies of the N (nucleocapsid) protein bound to the genomic RNA. The M protein holds dominant cellular immunogenicity and has been determined as a protective antigen in humoral responses, which suggests it would serve as a potential target in vaccine design (4).
REFERENCES:1) Zhu et al. N Engl J Med. 2020 Feb 20;382(8):727-733.
2) Kiyotani et al. J Hum Genet. 2020 Jul;65(7):569-575.
3) Neuman et al. J Struct Biol. 2011;174(1):11–22.
4) Liu et al. J Infect Dis. 2010;202(8):1171-80.

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