SARS-CoV Envelope Antibody Cat. No.: 3533

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Virus
HOMOLOGY: Predicted reactivity based on immunogen sequence: SARS-CoV2 Envelope protein: (identity 82%, homology 91%)
IMMUNOGEN: Anti-SARS-CoV Envelope antibody (3533) was raised against a peptide corresponding to 11 amino acids near the carboxy terminus of SARS-CoV Envelope protein.

The immunogen is located within the last 50 amino acids of SARS-CoV Envelope.
TESTED APPLICATIONS: ELISA
APPLICATIONS: SARS-CoV Envelope antibody can be used for the detection of SARS-CoV Envelope protein in ELISA. It will detect 5 ng of free peptide at 1 μg/mL.

psi-iconProperties
PURIFICATION:SARS-CoV Envelope Antibody is affinity chromatography purified via peptide column.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:SARS-CoV Envelope Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:SARS-CoV Envelope antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

psi-iconAdditional Info
OFFICIAL SYMBOL:E
ALTERNATE NAMES:SARS-CoV Envelope Antibody: sM, 4, Envelope small membrane protein, E protein
ACCESSION NO.:P59637
PROTEIN GI NO.:30173401
GENE ID:1489671
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:SARS Envelope Antibody: A novel coronavirus has recently been identified as the causative agent of SARS (Severe Acute Respiratory Syndrome). Coronaviruses are a major cause of upper respiratory diseases in humans. The genomes of these viruses are positive-stranded RNA approximately 27-31kb in length. SARS infection can be mediated by the binding of the viral spike protein, a glycosylated 139 kDa protein and the major surface antigen of the virus, to the angiotensin-converting enzyme 2 (ACE2) on target cells. This binding can be blocked by a soluble form of ACE2. Envelope protein is a small polypeptide that contains at least one α-helical transmembrane domain. It involves in several aspects of the virus's life cycle, such as assembly, budding, envelope formation, and pathogenesis. E protein has membrane permeabilizing activity, which provides a possible rationale to inhibit in vitro ion channel activity of some synthetic coronavirus E proteins, and also viral replication.
REFERENCES:1) Marra et al. Science 2003;300:1399-404.
2) Rota et al. Science 2003;300:1394-9.
3) Navas-Nartin et al. J Neurovirol. 2004;10:75-85.
4) Pervushin et al. PLoS Pathog. 2009; 5(7): e1000511.

ANTIBODIES FOR RESEARCH USE ONLY.

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