SARS-CoV-2 (COVID-19) South African variant (B.1.351) Spike S1 (K417N, E484K, N501Y) Recombinant Protein Cat. No.: 20-183

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psi-iconSpecifications
SPECIES:SARS Spike Protein
SOURCE SPECIES:HEK293 cells
SEQUENCE:Val16-Arg685 (N501Y, K417N, E484K)
FUSION TAG:His
TESTED APPLICATIONS:ELISA, WB
APPLICATIONS:SDS-PAGE
psi-iconProperties
PURITY:> 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC

Endotoxin level is less than 1EU per ug by the LAL method.
PHYSICAL STATE:Lyophilized
BUFFER:20mM PB (pH 7.4). 5 % trehalose is added as a protectant before lyophilization.
STORAGE CONDITIONS:Store in working aliquots at -20˚C. Avoid freeze/thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:S protein, Spike glycoprotein, S glycoprotein, Spike protein
ACCESSION NO.:YP_009724390.1
psi-iconBackground and References
BACKGROUND:SARS-CoV-2 exploits angiotensin-converting enzyme 2 (ACE2) as a receptor to invade cells. It has been reported that the UK and South African strains may have higher transmission capabilities, eventually in part due to amino acid substitutions on the SARS-CoV-2 Spike protein. The results of a study show the N501Y replacement in this region of the interface (present in both the UK and South African strains) should be favorable for the interaction with ACE2, while the K417N and E484K substitutions (South African strain) would seem neutral or even unfavorable.

FOR RESEARCH USE ONLY.

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