SARS-CoV-2 (COVID-19) S2 Recombinant Protein Cat. No.: 11-184

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psi-iconSpecifications
SPECIES:SARS-CoV-2
SOURCE SPECIES:HEK293 cells
SEQUENCE:N/A
FUSION TAG:His Tag
TESTED APPLICATIONS:ELISA, WB
APPLICATIONS:This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 60.0 kDa. The protein migrates as 70-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
psi-iconProperties
PURITY:>95% as determined by SDS-PAGE.
PREDICTED MOLECULAR WEIGHT:60.0 kDa
PHYSICAL STATE:Liquid
BUFFER:20 mM PB, 300 mM NaCl, pH7.4
STORAGE CONDITIONS:Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:Spike,S2 protein,Spike glycoprotein Subunit2,S glycoprotein Subunit2,Spike protein S2,COVID-19
ACCESSION NO.:QHD43416.1
OFFICIAL SYMBOL:S
GENE ID:43740568
psi-iconBackground and References
BACKGROUND:It's been reported that SARS-CoV-2 can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
REFERENCES:1) Wan Y, et al. J Virol. 2020. pii: JVI.00127-20.
2) Benvenuto D, et al. J Med Virol. 2020.
3) Chang CY, et al. AMB Express. 2020. 10(1):20.

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