SARS-CoV-2 (COVID-19) S1 Recombinant Protein Cat. No.: 97-086

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psi-iconSpecifications
SPECIES:SARS-CoV-2
SOURCE SPECIES:HEK293 cells
SEQUENCE:Val 16 - Arg 685
FUSION TAG:Fc Tag
TESTED APPLICATIONS:WB
APPLICATIONS:This recombinant protein can be used for WB. For research use only.
psi-iconProperties
PURITY:>95% as determined by SDS-PAGE.
PREDICTED MOLECULAR WEIGHT:101.5 kDa
PHYSICAL STATE:Lyophilized
BUFFER:Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.
STORAGE CONDITIONS:Lyophilized protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:S1 protein, Spike glycoprotein Subunit1, S glycoprotein Subunit1, Spike protein S1
ACCESSION NO.:QHD43416.1
OFFICIAL SYMBOL:S
GENE ID:43740568
psi-iconBackground and References
BACKGROUND:Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, DPP4, CEACAM etc.. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
REFERENCES:1) Wan Y, et al. J Virol. 2020. pii: JVI.00127-20.
2) Benvenuto D, et al. J Med Virol. 2020.
3) Chang CY, et al. AMB Express. 2020. 10(1):20.

FOR RESEARCH USE ONLY.

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