SARS-CoV-2 (COVID-19) S1 Recombinant Protein Cat. No.: 92-727

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psi-iconSpecifications
SPECIES:SARS-CoV-2
SOURCE SPECIES:Mammalian cells
SEQUENCE:Gln14-Arg685
FUSION TAG:C-mFc tag
APPLICATIONS:This recombinant protein can be used for biological assays. For research use only.
psi-iconProperties
PURITY:Greater than 95% as determined by reducing SDS-PAGE.
PREDICTED MOLECULAR WEIGHT:101.3kDa, 130-160kDa
PHYSICAL STATE:Liquid
BUFFER:Supplied as a 0.2 uM filtered solution of PBS, pH 7.4
STORAGE CONDITIONS:Reconstituted protein solution should be store below -20˚C.
psi-iconAdditional Info
ALTERNATE NAMES:S1 protein; 2019-nCoV S1 protein; coronavirus S1 Protein; cov S1 Protein
ACCESSION NO.:QHD43416.1
OFFICIAL SYMBOL:S
GENE ID:43740568
psi-iconBackground and References
BACKGROUND:Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

FOR RESEARCH USE ONLY.

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