| SPECIES: | SARS-CoV-2 (COVID-19) Spike Protein |
| SOURCE SPECIES: | Mammalian cells |
| SEQUENCE: | Arg319-Phe541(K458R) |
| FUSION TAG: | C-6His tag |
| APPLICATIONS: | This recombinant protein can be used for biological assays. For research use only. |
Specifications| PURITY: | Greater than 95% as determined by reducing SDS-PAGE. |
| PREDICTED MOLECULAR WEIGHT: | 25.9kDa, 35kDa |
| PHYSICAL STATE: | Liquid |
| BUFFER: | Supplied as a 0.2 uM filtered solution of PBS, pH 7.4 |
| STORAGE CONDITIONS: | Reconstituted protein solution should be store below -20˚C. |
| ALTERNATE NAMES: | 2019-nCov RBD Protein; 2019-nCoV Spike RBD Protein |
| ACCESSION NO.: | QHD43416.1 |
| OFFICIAL SYMBOL: | S |
| GENE ID: | 43740568 |
| BACKGROUND: | The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.Some findings indicated that the mutated viruses may be evolved to acquire remarkably increased infectivity. |
FOR RESEARCH USE ONLY.
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