SARS-CoV-2 (COVID-19) PL-Pro Recombinant Protein Cat. No.: 10-404

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psi-iconSpecifications
SPECIES:SARS-CoV-2
SOURCE SPECIES:E. coli
SEQUENCE:Glu1564-IIe1877
FUSION TAG:N-His Tag
APPLICATIONS:Immunogen
BIOLOGICAL ACTIVITY: Testing in progress
psi-iconProperties
PURITY:>90% as determined by SDS-PAGE quantitative densitometry by Coomassie Blue Staining.
PREDICTED MOLECULAR WEIGHT:38.59kDa
PHYSICAL STATE:Lyophilized
BUFFER:Supplied as lyophilized from PBS,pH7.5,4M urea
STORAGE CONDITIONS:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 ˚C for one week. Store at -20 to -80 ˚C for twelve months from the date of receipt.
psi-iconAdditional Info
ALTERNATE NAMES:nsp3,PL-PRO,Papain-like proteinase,Peptidase C16 domain
ACCESSION NO.:QHD43415.1
psi-iconBackground and References
BACKGROUND:The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. Targeting PLpro with antiviral drugs may have an advantage in not only inhibiting viral replication but also inhibiting the dysregulation of signaling cascades in infected cells that may lead to cell death in surrounding, uninfected cells.

FOR RESEARCH USE ONLY.

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