SARS-CoV-2 (COVID-19) ORF9b Antibody Cat. No.: 9191

Availability: In stock

$0.00

 Price Options

$0.00
psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Virus
HOMOLOGY: Predicted reactivity based on immunogen sequence: SARS-CoV ORF9b proteins: (50%)
IMMUNOGEN: Anti-SARS-CoV-2 (COVID-19) ORF9b antibody (9191) was raised against a peptide corresponding to 14 amino acids near the amino terminus of SARS-CoV-2 (COVID-19) ORF9b protein.

The immunogen is located in the first 50 amino acids of the SARS-CoV-2 (COVID-19) ORF9b protein.
TESTED APPLICATIONS: ELISA, WB
APPLICATIONS: WB: 2 μg/mL

Antibody validated: SARS-CoV-2 (COVID-19) ORF9b antibody can detect 2 ng of free peptide at 1 μg/mL in ELISA.

psi-iconProperties
PURIFICATION:SARS-CoV-2 (COVID-19) ORF9b Antibody is affinity chromatography purified via peptide column.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:SARS-CoV-2 (COVID-19) ORF9b Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:SARS-CoV-2 (COVID-19) ORF9b antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

psi-iconAdditional Info
OFFICIAL SYMBOL:ORF9b
ALTERNATE NAMES:Accessory protein 9b, ORF-9b, Protein 9b
ACCESSION NO.:P0DTD2.1
PROTEIN GI NO.:1835921959
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. ORF9b plays a role in the inhibition of host innate immune response by targeting the mitochondrial-associated adapter MAVS. Mechanistically, it usurps the E3 ligase ITCH to trigger the degradation of MAVS, TRAF3, and TRAF6. In addition, it causes mitochondrial elongation by triggering ubiquitination and proteasomal degradation of dynamin-like protein 1/DNM1L(3).
REFERENCES:1) Gorbalenya. bioRxiv: 2020.
2) Hui et al. Int J Infect Dis. 2020;91:264-266.
3) Shi. et al. J. Immunol 2014; 193:3090-3089

ANTIBODIES FOR RESEARCH USE ONLY.

For additional information, visit ProSci's Terms & Conditions Page.