SARS-CoV-2 (COVID-19) NSP8 Recombinant Protein Cat. No.: 10-415

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psi-iconSpecifications
SPECIES:SARS-CoV-2
SOURCE SPECIES:E. coli
SEQUENCE:Ala1-Gln198
FUSION TAG:N-His Tag
APPLICATIONS:Immunogen
BIOLOGICAL ACTIVITY: Testing in progress
psi-iconProperties
PURITY:>85% as determined by SDS-PAGE quantitative densitometry by Coomassie Blue Staining.
PREDICTED MOLECULAR WEIGHT:24.18kDa
PHYSICAL STATE:Lyophilized
BUFFER:Supplied as lyophilized from PBS, pH7.5
STORAGE CONDITIONS:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 ˚C for one week. Store at -20 to -80 ˚C for twelve months from the date of receipt.
psi-iconAdditional Info
ALTERNATE NAMES:SARS-CoV 2 nsp8
ACCESSION NO.:YP_009725304.1
psi-iconBackground and References
BACKGROUND:Cleavage by the viral main protease, 3CLpro results in generating the nsp8 protein, The nsp8 protein has been shown to associate with several other nsps and to colocalize with these nsps in cytoplasmic complexes that are important for viral RNA synthesis. It forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers. Nsp8 was shown to have RNA-dependent RNA polymerase (RdRp) activity that could be involved in producing primers utilized by nsp12 which is normally accepted to be the RdRp for SARS-CoV.

FOR RESEARCH USE ONLY.

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