SARS-CoV-2 (COVID-19) NSP7 Recombinant Protein Cat. No.: 97-096

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psi-iconSpecifications
SPECIES:SARS-CoV-2
SOURCE SPECIES:E. coli
SEQUENCE:Ser 1 - Gln 83
FUSION TAG:His Tag at C-terminus
TESTED APPLICATIONS:WB
APPLICATIONS:This recombinant protein can be used for WB. For research use only.
psi-iconProperties
PURITY:>95% as determined by SDS-PAGE. >90% as determined by SEC-MALS.
PREDICTED MOLECULAR WEIGHT:12 kDa
PHYSICAL STATE:Liquid
BUFFER:PBS, pH7.4 with glycerol
STORAGE CONDITIONS:Working aliquots should be stored at -70˚C or lower. Avoid repeated freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:NSP7, nsp7, Non-structural protein 7, COVID-19
ACCESSION NO.:YP_009725303.1
psi-iconBackground and References
BACKGROUND:During the formation of the coronaviral replication/transcription complex, essential steps include processing of the conserved polyprotein nsp7-10 region by the main protease Mpro and subsequent complex formation of the released nsp's. Upon infecting host cells, coronaviruses assemble a multi-subunit RNA-synthesis complex of viral non-structural proteins (nsp) responsible for the replication and transcription of the viral genome. non-structural proteins 7 (NSP7) forms a hexadecamer with nsp8 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.
REFERENCES:1) Krichel B, et al. Biochem J. 2020. 477(5):1009-1019.
2) Kirchdoerfer RN, et al. Nat Commun. 2019. 10(1):2342.

FOR RESEARCH USE ONLY.

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