SARS-CoV-2 (COVID-19) NSP6 Antibody Cat. No.: 9177

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Virus
HOMOLOGY: Predicted reactivity based on immunogen sequence: SARS-CoV NSP6 protein: (94%)
IMMUNOGEN: Anti-SARS-CoV-2 (COVID-19) NSP6 antibody (9177) was raised against a peptide corresponding to 18 amino acids in the center of SARS-CoV-2 (COVID-19) NSP6 protein.

The immunogen is located in between 230-280 amino acids of the SARS-CoV-2 (COVID-19) NSP6 protein.
TESTED APPLICATIONS: ELISA
APPLICATIONS: Antibody validated: SARS-CoV-2 (COVID-19) NSP6 antibody can detect 2ng of free peptide at 1 μg/mL in ELISA.

psi-iconProperties
PURIFICATION:SARS-CoV-2 (COVID-19) NSP6 Antibody is affinity chromatography purified via peptide column.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:SARS-CoV-2 (COVID-19) NSP6 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:SARS-CoV-2 (COVID-19) NSP6 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

psi-iconAdditional Info
OFFICIAL SYMBOL:Non-structural protein 6
ALTERNATE NAMES:NSP6
ACCESSION NO.:YP_009742613.1
PROTEIN GI NO.:1826688923
GENE ID:43740578
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. NSP6 plays a role in the initial induction of autophagosomes from host reticulum endoplasmic. Later, it limits the expansion of these phagosomes that are no longer able to deliver viral components to lysosomes (3,4).
REFERENCES:1) Gorbalenya. bioRxiv: 2020.
2) Hui et al. Int J Infect Dis. 2020;91:264-266.
3) Angelini et. al. DNA Cell Biol. 33:122-127 (2014)
4) Cottam et. al. Autophagy 2014; 10:1426-1441

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