SARS-CoV-2 (COVID-19) NSP1 Recombinant Protein Cat. No.: 97-095

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psi-iconSpecifications
SPECIES:SARS-CoV-2
SOURCE SPECIES:E. coli
SEQUENCE:Met 1 - Gly 180
FUSION TAG:His Tag at C-terminus
TESTED APPLICATIONS:WB
APPLICATIONS:This recombinant protein can be used for WB. For research use only.
psi-iconProperties
PURITY:>90% as determined by SDS-PAGE.
PREDICTED MOLECULAR WEIGHT:22-25 kDa
PHYSICAL STATE:Lyophilized
BUFFER:PBS, Arginine, pH7.4, trehalose is added as protectant before lyophilization.
STORAGE CONDITIONS:Lyophilized protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -70˚C or lower. Avoid repeated freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:NSP1, nsp1, Leader protein, Host translation inhibitor nsp1, COVID-19
ACCESSION NO.:YP_009725297.1
psi-iconBackground and References
BACKGROUND:The viral nonstructural protein 1 (nsP1) is the only membrane-associated protein that anchors the replication complex to the cellular membranes. NSP1 inhibits host translation by interacting with the 40S ribosomal subunit. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. Viral mRNAs are not susceptible to nsp1-mediated endonucleolytic RNA cleavage thanks to the presence of a 5'-end leader sequence and are therefore protected from degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response.
REFERENCES:1) Dong S, et al. J Med Virol. 2020.
2) Gottipati K, et al. Virology. 2020. 544:31-41.

FOR RESEARCH USE ONLY.

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