SARS-CoV-2 (COVID-19) E Recombinant Protein Cat. No.: 11-072

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psi-iconSpecifications
SPECIES:SARS-CoV-2
SOURCE SPECIES:E. coli
SEQUENCE:Met1-Val75
FUSION TAG:N-His-sumo Tag
APPLICATIONS:Immunogen
psi-iconProperties
PURITY:>90% as determined by SDS-PAGE
PREDICTED MOLECULAR WEIGHT:21.04kDa
PHYSICAL STATE:Lyophilized
BUFFER:Supplied as lyophilized from PBS, pH7.5. Please reconstitute the protein with ddH2O to the concentration with 1mg/ml.
STORAGE CONDITIONS:Use a manual defrost freezer and avoid repeated freeze thaw cycles.Store at 2 to 8 ˚C for one week .Store at -20 to -80 ˚C for twelve months from the date of receipt.
psi-iconAdditional Info
ALTERNATE NAMES:2019-nCoV E protein,2019-nCoV sM protein
ACCESSION NO.:QHD43418.1
psi-iconBackground and References
BACKGROUND:Coronavirus envelope (E) proteins are short (100 residues) polypeptides that contain at least one transmembrane (TM) domain and a cluster of 2-3 juxtamembrane cysteines. These proteins are involved in viral morphogenesis and tropism, and their absence leads in some cases to aberrant virions, or to viral attenuation. In common to other viroporins, coronavirus envelope proteins increase membrane permeability to ions, plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis. Activates the host NLRP3 inflammasome, leading to IL-1beta overproduction.

FOR RESEARCH USE ONLY.

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