RSRC1 Antibody Cat. No.: 5607

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human, Mouse, Rat
HOMOLOGY: Predicted species reactivity based on immunogen sequence: Bovine: (100%)
IMMUNOGEN: RSRC1 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human RSRC1.

The immunogen is located within the last 50 amino acids of RSRC1.
TESTED APPLICATIONS: ELISA, IF, IHC-P, WB
APPLICATIONS: RSRC1 antibody can be used for detection of RSRC1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in human samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
POSITIVE CONTROL:1) Cat. No. 1211 - HepG2 Cell Lysate

psi-iconProperties
PURIFICATION:RSRC1 Antibody is affinity chromatography purified via peptide column.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:RSRC1 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:RSRC1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

psi-iconAdditional Info
OFFICIAL SYMBOL:RSRC1
ALTERNATE NAMES:RSRC1 Antibody: BM-011, SFRS21, SRrp53, SRRP53, BM-011SRrp53
ACCESSION NO.:NP_057709
PROTEIN GI NO.:38488727
GENE ID:51319
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:RSRC1 Antibody: The arginine/serine-rich coiled-coil 1 protein (RSRC1) was initially identified as a non-snRNP splicing factor that has a role in both the constitutive and alternative splicing of pre-mRNA molecules. In cellular nuclear extracts immunodepleted of RSRC1, the second step of pre-mRNA splicing is blocked; recombinant RSRC1 is able to restore splicing activity. RSRC1 has also been reported to be associated with schizophrenia as well as a unique marker of bone marrow-derived stem cells that also express the cdc34 marker.
REFERENCES:1) Cazalla D, Newton K, and Caceres JF. A noel SR-related protein is required for the second step of pre-mRNA splicing. Mol. Cell. Biol.2005; 25:2969-80.
2) Potkin SG, Turner JA, Fallon JA, et al. Gene discovery through imaging genetics: identification of two novel genes associated with schizophrenia. Mol. Psych.2009; 14:416-28.
3) Zhang QH, Ye M, Wu XY, et al. Cloning and functional analysis of cDNAs with open reading frames for 300 previously unidentified genes expressed in CD34+ hematopoietic stem/progenitor cells. Genome Res./i> 2008; 18:640-3.

ANTIBODIES FOR RESEARCH USE ONLY.

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