Rhesus macaque / TROP-2 / TACSTD2 Recombinant Protein Cat. No.: 11-141

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psi-iconSpecifications
SPECIES:Cynomolgus, Rhesus macaque
SOURCE SPECIES:HEK293 cells
SEQUENCE:Gln 31 - Thr 274
FUSION TAG:His Tag
TESTED APPLICATIONS:WB
APPLICATIONS:This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 29.4 kDa. The protein migrates as 38-48 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
psi-iconProperties
PURITY:>95% as determined by SDS-PAGE.
PREDICTED MOLECULAR WEIGHT:29.4 kDa
PHYSICAL STATE:Lyophilized
BUFFER:PBS, pH7.4
STORAGE CONDITIONS:Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:TACSTD2,GA733-1,M1S1,TROP2
ACCESSION NO.:XP_001114599.1
OFFICIAL SYMBOL:TACSTD2
GENE ID:716334
psi-iconBackground and References
BACKGROUND:TROP-2 is a single-copy gene in human cells, and encodes a type-1 transmembrane glycoprotein which is over-expressed in various malignancies, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1. TROP-2 is related to epithelial cell adhesion molecule (EpCAM), also called TROP-1, gp40, and KSA. Trop-1 and Trop-2 are homologous to serum IGF-II-binding proteins and appear as signal transducers. Thus, they likely represent novel cell-surface receptors and may play a role in regulating the growth of carcinoma cells.
REFERENCES:1) Simms A., et al., 2016, Diagn. Cytopathol. 44:26-31.
2) Fornaro M., et al., 1995, Int. J. Cancer. 62(5):610-618.

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