Rhesus macaque OX40 Ligand / TNFSF4 Recombinant Protein Cat. No.: 11-510

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psi-iconSpecifications
SPECIES:Rhesus monkey
SOURCE SPECIES:HEK293 cells
SEQUENCE:Gln 51 - Leu 183
FUSION TAG:Mouse IgG Fc Tag
TESTED APPLICATIONS:ELISA, WB
APPLICATIONS:This protein carries a mouse IgG2a Fc tag at the N-terminus. The protein has a calculated MW of 42.5 kDa. The protein migrates as 47-58 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
psi-iconProperties
PURITY:>90% as determined by SDS-PAGE.
PREDICTED MOLECULAR WEIGHT:42.5 kDa
PHYSICAL STATE:Lyophilized
BUFFER:50 mM Tris, 100 mM Glycine, pH7.5
STORAGE CONDITIONS:Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:OX40L,TNFSF4,CD252,Glycoprotein Gp34,TXGP1,CD134 ligand,CD134L
ACCESSION NO.:XP_017808006.1
psi-iconBackground and References
BACKGROUND:Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L), TAX transcriptionally-activated glycoprotein 1 and CD252, which belongs to the tumor necrosis factor family. TNFSF4 is the ligand for CD134 and is expressed on such cells as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. Furthermore, similar to other TNF superfamily members, membrane-bound OX40 Ligand (TNFSF4) exists as a homotrimer. Human TNFSF4 shares 46% amino acid sequence identity with its mouse counterpart.
REFERENCES:1) Compaan D.M., et al., 2006, Structure 14:1321-1330.
2) Maizels RM., et al., 2003, Nat. Rev. Immunol. 3 (9): 733–44.

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