Recombinant SARS-CoV-2 (COVID-19) S-IgM Neutralizing Antibody [8A5] Cat. No.: 93-307

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psi-iconSpecifications
HOST SPECIES:Human
SPECIES REACTIVITY: Virus
IMMUNOGEN: Cultured in vitro under conditions free from animal derived components.
TESTED APPLICATIONS: ELISA, Neut
APPLICATIONS: Immunoreactivity: 80–120 % compared to the reference sample in an ELISA test.
SPECIFICITY: Antibody recognizes 2019-nCoV S Protein/ 2019-nCoV S-RBD Protein and block ACE-2 receptorbinding

psi-iconProperties
PURIFICATION:≥95 %
CLONALITY:Monoclonal
ISOTYPE:Human IgM
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:PBS, pH 7.4
CONCENTRATION:2.0 mg/ml (+/- 10 %)
STORAGE CONDITIONS:24 months from manufacturing at <-20 ˚C; 1 month, 2 to 8 ˚C under sterile conditions.

psi-iconAdditional Info
OFFICIAL SYMBOL:S
ALTERNATE NAMES:SARS-CoV-2 (COVID-19) Spike S1 Antibody: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Surface Glycoprotein, Spike protein
ACCESSION NO.:QHD43416
PROTEIN GI NO.:1791269090
GENE ID:43740568
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

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