Apoptosis Research

Apoptosis is a process of programmed cell death that removes old and damaged cells to maintain homeostasis in multicellular organisms. The term “apoptosis” was adopted from the Greek word for the process of leaves falling from trees or petals falling from flowers (1) and was adopted to differentiate naturally occurring developmental cell death from the necrosis that results from acute tissue injury.

Apoptosis follows a scripted choreography of biochemical events that lead to characteristic morphological changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, chromosomal DNA fragmentation, and complete mRNA decay, and subsequent cell death. The average human adult loses about 50 billion cells a day to apoptosis which is important in developmental regulation and maintaining a healthy body.

Errors in the regulation of apoptosis are associated with a variety of disorders such as cancers and the progression of HIV to AIDS. ProSci offers a variety of apoptosis recombinant proteins to aid in the research of the role apoptosis plays in human diseases and how they can be treated. 

(1)  Kerr JF, Wyllie AH, Currie AR (August 1972). "Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics"Br J Cancer26 (4): 239–57

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