SARS-CoV-2 Reagent Related Citations

COVID-19 is an acute respiratory disease caused by novel coronavirus SARS-CoV-2  also known as 2019-nCoV. On March 11, 2020, the World Health Organization (WHO) characterized COVID-19 as a pandemic. COVID-19 coronavirus SARS-CoV-2 belongs to the Betacoronavirus genus originating from bats. Betacoronaviruses can infect mammals, are zoonotic pathogens and can cause severe respiratory disease in humans. Other viruses in this family are SARS coronavirus and MERS coronavirus. COVID-19 (SARS-CoV-2) has approximately 79% sequence identity to SARS-CoV and 50% to MERS-CoV. In addition, homology modeling shows COVID-19 (SARS-CoV-2) has a similar receptor-binding domain structure as SARS-CoV which suggests SARS-CoV-2 uses ACE2 receptor in humans for infection.

Recent Publications with ProSci's SARS-CoV-2 Reagents

  • Sun, Y., et al. (2021). Restriction of SARS-CoV-2 replication by targeting programmed −1 ribosomal frameshifting. Proceedings of the National Academy of Sciences, 118(26), e2023051118.
  • Xian, M., et al. (2021). Fast SARS-CoV-2 virus detection using disposable cartridge strips and a semiconductor-based biosensor platform. Journal of Vacuum Science and Technology B, 39(3), 033202.
  • Wei, J., et al. (2021). Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection. Cell, 184(1), 76-91.e13.
  • Nuovo, G., et al. (2021). Endothelial cell damage is the central part of COVID-19 and a mouse model induced by injection of the S1 subunit of the spike protein. Annals of Diagnostic Pathology, 51, 151682.
  • Magro, C. M., et al. (2021). Severe COVID-19: A multifaceted viral vasculopathy syndrome. Annals of Diagnostic Pathology, 50, 151645.
  • Singh, D.K., et al. Responses to acute infection with SARS-CoV-2 in the lungs of rhesus macaques, baboons and marmosets. Nat Microbiol 6, 73–86 (2021).
  • Balatskaya, M. N., et al. (2021). The Missing Protein: Is T-Cadherin a Previously Unknown GPI-Anchored Receptor on Platelets? Membranes, 11(3), 218.
  • Ko, C. J., et al. (2020). Discordant anti‐SARS‐CoV ‐2 spike protein and RNA staining in cutaneous perniotic lesions suggests endothelial deposition of cleaved spike protein. Journal of Cutaneous Pathology, 48(1), 47–52.

ProSci is committed to furthering global research efforts to understand this novel virus and the disease it causes by offering a broad catalog of SARS-CoV-2 antibodies, recombinant proteins, and related research reagents. By offering reagents to viral accessory proteins, ProSci supports research into unique approaches in diagnostics (e.g. measuring patient serum antibody levels of ORF3b and ORF8) and therapeutics (e.g. inhibiting some of the accessory proteins can aid in overcoming immune evasion and suppression). Contact us to see how we can help.