ZP4 Antibody
CATALOG NUMBER: 56-605- Clonality: Polyclonal
- Tested Applications: IHC-P, WB
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- IMMUNOGEN: This ZP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 445-474 amino acids from the C-terminal region of human ZP4.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: IHC-P, WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50 - PREDICTED MOLECULAR WEIGHT: 59 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: ZP4
- ADDITIONAL NAMES: Zona pellucida sperm-binding protein 4, Zona pellucida glycoprotein 4, Zp-4, Zona pellucida protein B, Processed zona pellucida sperm-binding protein 4, ZP4, ZPB
- Protein Accession Number: Q12836
- PROTEIN GI NUMBER: 46397080
- NCBI GENE ID NUMBER: 57829
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- The zona pellucida is an extracellular matrix thatsurrounds the oocyte and early embryo. It is composed primarily ofthree or four glycoproteins with various functions duringfertilization and preimplantation development. The nascent proteincontains a N-terminal signal peptide sequence, a conserved ZPdomain, a consensus furin cleavage site, and a C-terminaltransmembrane domain. It is hypothesized that furin cleavageresults in release of the mature protein from the plasma membranefor subsequent incorporation into the zona pellucida matrix.However, the requirement for furin cleavage in this process remainscontroversial based on mouse studies. Previously, this gene hasbeen referred to as ZP1 or ZPB and thought to have similarfunctions as mouse Zp1. However, a human gene with highersimilarity and chromosomal synteny to mouse Zp1 has been assignedthe symbol ZP1 and this gene has been assigned the symbol ZP4.
- 1: Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- 2: McCauley, J.L., et al. Genes Immun. 10(7):624-630(2009)
- 3: Nakano, M., et al. Proc. Natl. Acad. Sci. U.S.A. 106(31):12838-12842(2009)
- 4: Choudhury, S., et al. J. Reprod. Immunol. 79(2):137-147(2009)
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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$35 Dry Ice Shipment fee may be required on some items.
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