- Trial Size
ZNF687 Antibody
CATALOG NUMBER: 6861- Clonality: Polyclonal
- Tested Applications: ELISA, IF, WB
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 0.02 mg | 0.1 mg
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- HOMOLOGY: Predicted species reactivity based on immunogen sequence: Mouse: (82%)
- IMMUNOGEN: ZNF687 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human ZNF687.
The immunogen is located within amino acids 1160 - 1210 of ZNF687. - CONJUGATE: Unconjugated
- TESTED APPLICATIONS: ELISA, IF, WB
- APPLICATION NOTE: ZNF687 antibody can be used for detection of ZNF687 by Western blot at 0.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. - SPECIFICITY: ZNF687 antibody is human specific. At least three isoforms of ZNF687 are known to exist; this antibody will only detect the largest isoform.
- POSITIVE CONTROL 1: Cat. No. 1201 - HeLa Cell Lysate
- POSITIVE CONTROL 2: Cat. No. 17-005 - Jurkat Cell Slide
- PREDICTED MOLECULAR WEIGHT: Predicted: 125 kDa
Observed: 129 kDa
Properties
- PURIFICATION: ZNF687 Antibody is affinity chromatography purified via peptide column.
- CLONALITY: Polyclonal
- ISOTYPE: IgG
- PHYSICAL STATE: Liquid
- BUFFER: ZNF687 Antibody is supplied in PBS containing 0.02% sodium azide.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: ZNF687 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: ZNF687
- ADDITIONAL NAMES: ZNF687 Antibody: KIAA1441, Zinc finger protein 687
- Protein Accession Number: NP_065883
- PROTEIN GI NUMBER: 24308227
- NCBI GENE ID NUMBER: 57592
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- ZNF687 Antibody: The zinc finger protein 687 (ZNF687) was initially identified as a translocation partner gene with RUNX1 in patients with acute myeloid leukemia (AML). Little is known of the function of the ZNF687 protein, but it has been shown to weakly interact with the Ring1/Rnf2 RING finger protein member of the Polycomb group of proteins, suggesting it may be involved in the chromatin-modifying complexes essential for embryonic development and stem cell renewal. Other evidence suggests that ZNF687 may be part of a transcriptional network that also includes ZNF592 and ZMYMD8.
- 1: Nguyen TT, Ma LN, Slovak ML, et al. Identification of novel Runx1 (AML1) translocation partner genes SH3D19, YTDf2, and ZNF687 in acute myeloid leukemia. Genes Chromo. Cancer 2006; 45:918-32.
- 2: Sanchez C, Sanchez I, Demmers JA, et al. Proteomics analysis of Ring1/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor. Mol. Cell Proteomics 2007; 6:820-34
- 3: Malovannaya A, Lanz RB, Jung SY, et al. Analysis of the human endogenous coregulator complexome. Cell 2011; 145:787-99.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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