- Trial Size
ZMYM4 Antibody
CATALOG NUMBER: 6139- Clonality: Polyclonal
- Tested Applications: ELISA, IHC-P
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 0.02 mg | 0.1 mg
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- HOMOLOGY: Predicted species reactivity based on immunogen sequence: Mouse: (94%)
- IMMUNOGEN: ZMYM4 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human ZMYM4.
The immunogen is located within the last 50 amino acids of ZMYM4. - CONJUGATE: Unconjugated
- TESTED APPLICATIONS: ELISA, IHC-P
- APPLICATION NOTE: ZMYM4 antibody can be used for detection of ZMYM4 by immunohistochemistry at 5 μg/mL.
Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested. - SPECIFICITY: At least three isoforms of ZMYM4 are known to exist; this antibody will detect all of them. ZMYM4 antibody is predicted not to cross-react with other ZMYM family members.
- PREDICTED MOLECULAR WEIGHT: 167 kDa
Properties
- PURIFICATION: ZMYM4 Antibody is affinity chromatography purified via peptide column.
- CLONALITY: Polyclonal
- ISOTYPE: IgG
- PHYSICAL STATE: Liquid
- BUFFER: ZMYM4 Antibody is supplied in PBS containing 0.02% sodium azide.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: ZMYM4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: ZMYM4
- ADDITIONAL NAMES: ZMYM4 Antibody: MYM, CDIR, ZNF262, ZNF198L3, KIAA0425, Zinc finger MYM-type protein 4, Zinc finger protein 262
- Protein Accession Number: AAI27114
- PROTEIN GI NUMBER: 117558167
- NCBI GENE ID NUMBER: 9202
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- ZMYM4 Antibody: Zinc-finger proteins contain DNA-binding domains characterized by the unique role of zinc and have a wide variety of functions such as transcriptional activation or repression. The protein folding and the DNA binding ability are governed by the coordination of a zinc ion. It has been found to be overexpressed in human lung adenocarcinomas and squamous cell carcinomas, and the overexpression of a fragment of the 3'UTR of the ZMYM4 mRNA termed Cell Death Inhibiting RNA (CDIR) protects HeLa cells from IFN-γ-induced apoptosis, suggesting that ZMYM4 may play a role in tumorigenesis.
- 1: Rosenfeld R and Margalit H. Zinc fingers: conserved properties that can distinguish between spurious and actual DNA-binding motifs. J. Biomol. Struct. Dyn. 1993; 11:557-70.
- 2: Gregory SG, Barlow KF, McLay KE, et al. The DNA sequence and biological annotation of human chromosome 1. Nature 2006; 441:315-21.
- 3: Sohal J, Reiter A, Goldman JM, et al. Cloning of ZNF237, a novel member of the MYM gene family that maps to human chromosome 13q11→q12. Cytogenet. Cell Genet. 2000; 89:24-8.
- 4: McDoniels-Silvers AL, Nimri CF, Stoner GD, et al. Differential gene expression in human lung adenocarcinomas and squamous cell carcinomas. Clin. Cancer Res. 2002; 8:1127-38.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
$65 Standard Overnight flat rate for as many products shipped within the United States.
$35 Dry Ice Shipment fee may be required on some items.
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