- Trial Size
ZIP8 Antibody
CATALOG NUMBER: 6095- Clonality: Polyclonal
- Tested Applications: ELISA, IF, IHC-P, WB
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 0.02 mg | 0.1 mg
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- HOMOLOGY: Predicted species reactivity based on immunogen sequence: Mouse: (89%), Rat: (89%)
- IMMUNOGEN: ZIP8 antibody was raised against a 18 amino acid synthetic peptide near the carboxy terminus of human ZIP8.
The immunogen is located within the last 50 amino acids of ZIP8. - CONJUGATE: Unconjugated
- TESTED APPLICATIONS: ELISA, IF, IHC-P, WB
- APPLICATION NOTE: ZIP8 antibody can be used for detection of ZIP8 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. - SPECIFICITY: ZIP8 antibody is predicted to not cross-react with other ZIP family members.
- POSITIVE CONTROL 1: Cat. No. 1306 - Human Spleen Tissue Lysate
- POSITIVE CONTROL 2: Cat. No. 10-901 - Human Spleen Tissue Slide
Properties
- PURIFICATION: ZIP8 Antibody is affinity chromatography purified via peptide column.
- CLONALITY: Polyclonal
- ISOTYPE: IgG
- PHYSICAL STATE: Liquid
- BUFFER: ZIP8 Antibody is supplied in PBS containing 0.02% sodium azide.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: ZIP8 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: Slc39a8
- ADDITIONAL NAMES: ZIP8 Antibody: ZIP8, PP3105, BIGM103, LZT-Hs6, ZIP8, Zinc transporter ZIP8, BCG-induced integral membrane protein in monocyte clone 103 protein
- Protein Accession Number: NP_071437
- PROTEIN GI NUMBER: 205830403
- NCBI GENE ID NUMBER: 64116
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- ZIP8 Antibody: The zinc transporter ZIP8, also known as SLC39A9, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. The zinc transporter family is divided into four subfamilies (I, II, LIV-1 and gufA). ZIP8 is glycosylated and located at the plasma membrane and mitochondria. It has been identified as the transporter responsible for transport of the toxic Cadmium cation. ZIP8 has also been suggested to play a role in the regulation of interferon-gamma expression in activated human T cells.
- 1: Dufner-Beattie J, Langmade SJ, Wang F, et al. Structure, function, and regulation of a subfamily of mouse zinc transporter genes. J. Biol. Chem.2003; 278:50142-50.
- 2: Eide DJ. The SLC39 family of metal ion transporters. Pflugers Arch.2004; 447:796-800.
- 3: Taylor KM and Nicohlson RI. The LZT proteins; the LIV-1 subfamily of zinc transporters. Biochim. Biophys. Acta.2003; 1611:16-30.
- 4: Dalton TP, He L, Wang B, et al. Identification of mouse SLC39A8 as the transporter responsible for cadmium-induced toxicity in the testis. Proc. Natl. Acad. Sci. USA2005; 102:3401-6.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
$65 Standard Overnight flat rate for as many products shipped within the United States.
$35 Dry Ice Shipment fee may be required on some items.
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