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ZC3H12A (CT) Antibody
CATALOG NUMBER: 9547- Clonality: Polyclonal
- Tested Applications: E, IF, IHC, WB
- Host Species: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Conjugate: Unconjugated
- Size: 0.02 mg | 0.1 mg
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human, Mouse, Rat
- HOMOLOGY: Predicted species reactivity based on immunogen sequence: Chimpanzee (100%); Monkey (100%); Pig (79%); Chicken (83%)
- IMMUNOGEN: Anti-ZC3H12A antibody (9547) was raised against a peptide corresponding to 14 amino acids near the carboxyl terminus of human ZC3H12A.
The immunogen is located within the last 50 amino acids of ZC3H12A. - CONJUGATE: Unconjugated
- TESTED APPLICATIONS: E, IF, IHC, WB
- APPLICATION NOTE: WB: 2 μg mL; IF: 10 μg mL; IHC: 1 μg mL.
Antibody validated: Western Blot in human, mouse and rat samples; Immunofluorescence in human samples; Immunohistochemistry in human, mouse and rat samples. All other applications and species not yet tested. - POSITIVE CONTROL 1: Cat. No. 1701-01 - Human Lung Lysate
- POSITIVE CONTROL 2: Cat. No. 11-701 - Human Testis Tissue Slide
- PREDICTED MOLECULAR WEIGHT: Predicted: 66 kD
Observed: 66 kD
Advanced Validation
- ISOFORMS: Human ZC3H12A has one isoform (599aa, 65.7kD). Mouse has one isoform (596aa, 65.6kD). Rat has one isoform (596aa, 65.9kD). 9547 can detect ZC3H12A in human, mouse, and rat.
Properties
- PURIFICATION: ZC3H12A Antibody is affinity chromatography purified via peptide column.
- CLONALITY: Polyclonal
- ISOTYPE: IgG
- PHYSICAL STATE: Liquid
- BUFFER: ZC3H12A Antibody is supplied in PBS containing 0.02% sodium azide.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: ZC3H12A antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: ZC3H12A
- ADDITIONAL NAMES: ZC3H12A Antibody: Endoribonuclease ZC3H12A, Monocyte chemotactic protein-induced protein 1, MCP-induced protein 1, MCPIP-1, Zinc finger CCCH domain-containing protein 12A
- Protein Accession Number: Q5D1E7.2
- PROTEIN GI NUMBER: 190485853
- NCBI GENE ID NUMBER: 80149
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- ZC3H12A Antibody: ZC3H12A is an MCP1 (CCL2; MIM 158105)-induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis. ZC3H12A inhibits the Wnt/beta-catenin signaling pathway activity and modulates epithelial-mesenchymal transition during clear cell renal cell carcinoma progression by targeting miRNAs. ZC3H12A ribonuclease can bind and cleave AURKA mRNA in MYCN-amplified neuroblastoma cells. ZC3H12A is a novel link between diabetogenic conditions and impaired insulin secretory capacity. ZC3H12A overexpression in human neuroblastoma cell lines causes cell-cycle arrest by G1/S checkpoint block.
- 1: Gorka et al. Oncogene. 2021; 40(50):6720-6735
- 2: Nowak et al. RNA Biol. 2021; 18(1):144-156
- 3: Tyka et al. Biochim Biophys Acta Mol Basis Dis. 2021; 1867(10):166199
- 4: Boratyn et al. J Cell Biochem. 2020; 121(5-6);3406-3425
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
$65 Standard Overnight flat rate for as many products shipped within the United States.
$35 Dry Ice Shipment fee may be required on some items.
Note: Online orders only accepted for shipment within the USA. Click here for the list of international distributors.
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