YTHD2 Antibody
CATALOG NUMBER: 58-440- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- HOMOLOGY: Predicted species reactivity based on immunogen sequence: Bovine, Monkey, Mouse
- IMMUNOGEN: This YTHD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 551-579 amino acids from the C-terminal region of human YTHD2.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
- PREDICTED MOLECULAR WEIGHT: 62 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: YTHDF2
- ADDITIONAL NAMES: YTH domain-containing family protein 2, CLL-associated antigen KW-14, High-glucose-regulated protein 8, Renal carcinoma antigen NY-REN-2, YTHDF2, HGRG8
- Protein Accession Number: Q9Y5A9
- PROTEIN GI NUMBER: 41019527
- NCBI GENE ID NUMBER: 51441
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- YTHDF2 is a member of the YTH (YT521-B homology)superfamily containing YTH domain. The YTH domain is typical forthe eukaryotes and is particularly abundant in plants. The YTHdomain is usually located in the middle of the protein sequence andmay function in binding to RNA. In addition to a YTH domain, thisprotein has a proline rich region which may be involved in signaltransduction. An Alu-rich domain has been identified in one of theintrons of this gene, which is thought to be associated with humanlongevity. In addition, reciprocal translocations between this geneand the Runx1 (AML1) gene on chromosme 21 has been observed inpatients with acute myeloid leukemia. This gene was initiallymapped to chromosome 14, which was later turned out to be apseudogene.
- 1: Nguyen, T.T., et al. Genes Chromosomes Cancer 45(10):918-932(2006)
- 2: Cardelli, M., et al. J. Gerontol.Biol. Sci. Med. Sci. 61(6):547-556(2006)
- 3: Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)
- 4: Stoilov, P., et al. Trends Biochem. Sci. 27(10):495-497(2002)
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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