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Home / Detection Sets / West Nile virus (WNV) Protein Detection Set
West Nile Virus Core AntibodyWest Nile Virus Core Antibody
West Nile Virus Core Antibody
West Nile Virus Core Antibody

West Nile virus (WNV) Protein Detection Set

CATALOG NUMBER: PSI-1809
  • Clonality: Polyclonal
  • Tested Applications: ELISA
  • Species Reactivity: Human
  • Size: 1 Set

Specifications

  • SPECIES REACTIVITY: Human
  • IMMUNOGEN: Rabbit polyclonal antibodies were raised against peptides corresponding to amino acid sequences from each of the corresponding proteins.
  • TESTED APPLICATIONS: ELISA
  • SET CONTENTS: WNV Matrix Antibody (IN), Catalog No. 3429 (50 μg)

    WNV Matrix Antibody (CT), Catalog No. 3431 (50 μg)

    WNV Core Antibody (CT), Catalog No. 3435 (50 μg)

    WNV Envelope Antibody (CT), Catalog No. 3441 (50 μg)

    WNV Matrix Peptide (IN), Catalog No. 3429P

    WNV Matrix Peptide (CT), Catalog No. 3431P

    WNV Core Peptide (CT), Catalog No. 3435P

    WNV Envelope Peptide (CT), Catalog No. 3441P

Properties

  • PURIFICATION: Antibodies are supplied as affinity chromatography purified IgG.
  • CLONALITY: Polyclonal
  • PHYSICAL STATE: Liquid
  • BUFFER: PBS containing 0.02% sodium azide.
  • CONCENTRATION: Antibody 1 mg/mL

    Peptide 200 μg/mL
  • STORAGE CONDITIONS: Stable at 4°C for three months, store at -20°C for up to one year.

Additional Info

  • USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background

  • West Nile Virus (WNV) is a member of the Flaviviridae, a plus-stranded virus family that includes St. Louis encephalitis virus, yellow fever virus, and Dengue virus. WNV was initially isolated in 1937 in the West Nile region of Uganda and has become prevalent in Africa, Asia, and Europe. It has rapidly spread across the United States with cases being observed in every continental state. Virus particles consist of a dense core made up of the core/capsid protein encapsulating the RNA genome surrounded by a membrane envelope embedded with envelope and matrix proteins. However, when the viruses are inside of infected cells, the matrix protein exists in its "pre-M" form as a heterodimer with the envelope proteins. Cleavage of the "pre-M” protein to its mature form occurs during release of the virus; this cleavage leads to the dissociation of the heterodimers. The viral core protein is thought to contribute to the WNV-associated inflammation via apoptosis induced though the caspase-9 pathway as delivery of core gene delivery into the striatum of mouse brain and skeletal muscle resulted in cell death and inflammation. The highly glycosylated envelope protein was shown to play a major role for WNV entry into target cells as WNV entry was inhibited by using a recombinant domain III from the envelope glycoprotein. The WNV receptor has recently been identified as alpha v beta 3 integrin.

    For images please see PDF data sheet
  • 1: Gould LH and Fikrig E. West Nile virus: a growing concern J. Clin. Invest. 2004; 113:1102-7.
  • 2: Wengler G and Wengler G. Cell-associated West Nile flavivirus is covered with E+pre-M protein heterodimers which are destroyed and reorganized by proteolytic cleavage during virus release. J. Virol. 1989; 2521-6.
  • 3: Yang JS, Ramanathan MP, Muthumani K, et al. Induction of inflammation by West Nile Virus capsid through the caspase-9 apoptotic pathway. Emerg. Infect. Dis. 2002; 8:1379-84.
  • 4: Wengler G and Wengler G. Cell-associated West Nile flavivirus is covered with E+pre-M protein heterodimers which are destroyed and reorganized by proteolytic cleavage during virus release. J. Virol. 1989; 2521-6.

Set Contents

Disclaimer

  • FOR RESEARCH USE ONLY
    For additional information, visit ProSci's Terms & Conditions Page.
  • Disclaimer: This product is for research use only.

CATALOG NUMBER: PSI-1809

  • Size: 1 Set
  • List Price: $640.00
Datasheet
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