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West Nile Virus Matrix Antibody
CATALOG NUMBER: 3431- Clonality: Polyclonal
- Tested Applications: E
- Host Species: Rabbit
- Species Reactivity: Virus
- Conjugate: Unconjugated
- Size: 0.02 mg | 0.1 mg
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Virus
- IMMUNOGEN: West Nile virus matrix antibody was raised against a synthetic peptide corresponding to 15 amino acids near the carboxy terminus of the West Nile virus matrix protein.
The immunogen is located within amino acids 220 - 270 of West Nile Virus Matrix. - CONJUGATE: Unconjugated
- TESTED APPLICATIONS: E
- APPLICATION NOTE: West Nile virus matrix antibody can be used for the detection of the West Nile virus matrix protein in ELISA. It will detect 10 ng of free peptide at 1 μg/mL.
Properties
- PURIFICATION: West Nile Virus Matrix Antibody is affinity chromatography purified via peptide column.
- CLONALITY: Polyclonal
- ISOTYPE: IgG
- PHYSICAL STATE: Liquid
- BUFFER: West Nile Virus Matrix Antibody is supplied in PBS containing 0.02% sodium azide.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: West Nile Virus Matrix antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: WNVgp1
- ADDITIONAL NAMES: West Nile Virus Matrix Antibody: Genome polyprotein, Core protein, NS1
- Protein Accession Number: NP_776012
- PROTEIN GI NUMBER: 27735300
- NCBI GENE ID NUMBER: 912267
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- West Nile Virus Matrix Antibody: West Nile Virus (WNV) is a member of the Flaviviridae, a plus-stranded virus family that includes St. Louis encephalitis virus, yellow fever virus, and Dengue virus. WNV was initially isolated in 1937 in the West Nile region of Uganda and has become prevalent in Africa, Asia, and Europe. It has rapidly spread across the United States with cases being observed in every continental state. Virus particles consist of a dense core made up of the core/capsid protein encapsulating the RNA genome surrounded by a membrane envelope embedded with envelope and matrix proteins. However, when the viruses are inside of infected cells, the matrix protein exists in its "pre-M" form as a heterodimer with the envelope proteins. Cleavage of the "pre-M" protein to its mature form occurs during release of the virus; this cleavage leas to the dissociation of the heterodimers. The WNV receptor has recently been identified as alpha v beta 3 integrin.
- 1: Gould LH and Fikrig E. West Nile virus: a growing concern. J. Clin. Invest. 2004; 113:1102-7.
- 2: Wengler G and Wengler G. Cell-associated West Nile flavivirus is covered with E+pre-M protein heterodimers which are destroyed and reorganized by proteolytic cleavage during virus release. J. Virol. 1989; 2521-6.
- 3: Chu JJ and Ng ML. Interaction of West Nile virus with α v β 3 integrin mediates virus entry into cells. J. Biol. Chem. 2004; 279:54533-41.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
$65 Standard Overnight flat rate for as many products shipped within the United States.
$35 Dry Ice Shipment fee may be required on some items.
Note: Online orders only accepted for shipment within the USA. Click here for the list of international distributors.
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