WAS Antibody
CATALOG NUMBER: 60-596- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- IMMUNOGEN: This WAS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 205-234 amino acids from the Central region of human WAS.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
- PREDICTED MOLECULAR WEIGHT: 53 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: WAS
- ADDITIONAL NAMES: Wiskott-Aldrich syndrome protein, WASp, WAS, IMD2
- Protein Accession Number: P42768
- NCBI GENE ID NUMBER: 7454
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- The Wiskott-Aldrich syndrome (WAS) family of proteinsshare similar domain structure, and are involved in transduction ofsignals from receptors on the cell surface to the actincytoskeleton. The presence of a number of different motifssuggests that they are regulated by a number of different stimuli,and interact with multiple proteins. Recent studies havedemonstrated that these proteins, directly or indirectly, associatewith the small GTPase, Cdc42, known to regulate formation of actinfilaments, and the cytoskeletal organizing complex, Arp2/3.Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessivedisease characterized by immune dysregulation andmicrothrombocytopenia, and is caused by mutations in the WAS gene.The WAS gene product is a cytoplasmic protein, expressedexclusively in hematopoietic cells, which show signalling andcytoskeletal abnormalities in WAS patients. A transcript variantarising as a result of alternative promoter usage, and containing adifferent 5' UTR sequence, has been described, however, itsfull-length nature is not known.
- 1: Burns, S.O., et al. Blood 115(26):5355-5365(2010)
- 2: Taylor, M.D., et al. Sci Transl Med(37), 37RA44 (2010) :
- 3: Rajmohan, R., et al. FEMS Yeast Res. 9(8):1226-1235(2009)
- 4: Dovas, A., et al. J. Cell. Sci. 122 (PT 21), 3873-3882 (2009) :
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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