Vinculin (phospho Tyr821) Antibody
CATALOG NUMBER: 80-022- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Conjugate: Unconjugated
- Size: 0.1 mg
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human, Mouse, Rat
- IMMUNOGEN: Vinculin (phospho Tyr821) antibody was raised against a peptide sequence around phosphorylation site of Tyrosine 821 (S-G-Y (p)-R-I) derived from Human Vinculin.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: Western Blot: 1:500~1:1000
- SPECIFICITY: The antibody detects endogenous level of Vinculin only when phosphorylated at tyrosine 821.
- PREDICTED MOLECULAR WEIGHT: 123 kDa
Properties
- PURIFICATION: Antibodies were purified by affinity-chromatography using epitope-specific peptide.
- CLONALITY: Polyclonal
- ISOTYPE: IgG
- PHYSICAL STATE: Liquid
- BUFFER: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: Store antibody at -20°C for up to one year.
Additional Info
- NCBI OFFICIAL SYMBOL: VCL
- ADDITIONAL NAMES: Vinculin
- Protein Accession Number: NP_003364.1
- PROTEIN GI NUMBER: 4507877
- NCBI GENE ID NUMBER: 7414
Background
- Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
- 1: Subauste MC, et al. (2004) J Cell Biol 165, 371-81
- 2: Olsen JV, et al. (2010) Sci Signal 3, ra3
- 3: Jørgensen C, et al. (2009) Science 326, 1502-9
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
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