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Home / Apoptosis / VHL Antibody [F5D4]
VHL Antibody [F5D4]
VHL Antibody [F5D4]

VHL Antibody [F5D4]

CATALOG NUMBER: 14-179
  • Clonality: Monoclonal
  • Tested Applications: IF, IHC, IP, WB
  • Host Species: Mouse
  • Species Reactivity: Human, Mouse, Rat
  • Conjugate: Unconjugated
  • Size: 50 uL

Specifications

  • HOST SPECIES: Mouse
  • SPECIES REACTIVITY: Human, Mouse, Rat
  • IMMUNOGEN: Recombinant protein of human VHL
  • CONJUGATE: Unconjugated
  • TESTED APPLICATIONS: IF, IHC, IP, WB
  • APPLICATION NOTE: WB: 1:500 - 1:2000
    IHC: 1:50 - 1:100
    IF: 1:50 - 1:100
    IP: 1:20 - 1:50
  • POSITIVE CONTROL 1: Mouse brain
  • POSITIVE CONTROL 2: Mouse lung
  • POSITIVE CONTROL 3: Tissue extracts
  • POSITIVE CONTROL 4: RAW264.7
  • PREDICTED MOLECULAR WEIGHT: Observed: 24kDa

Properties

  • PURIFICATION: Affinity purification
  • CLONALITY: Monoclonal
  • ISOTYPE: IgG
  • PHYSICAL STATE: Liquid
  • BUFFER: PBS with 0.02% sodium azide, pH7.3.
  • CONCENTRATION: batch dependent
  • STORAGE CONDITIONS: Store at 4°C. Avoid freeze / thaw cycles.

Additional Info

  • NCBI OFFICIAL SYMBOL: VHL
  • ADDITIONAL NAMES: VHL, von Hippel-Lindau tumor suppressor, HRCA1, RCA1, VHL1, elongin binding protein, von Hippel-Lindau syndrome, pVHL
  • NCBI GENE ID NUMBER: 7428
  • USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background

  • Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Disclaimer

  • FOR RESEARCH USE ONLY
    For additional information, visit ProSci's Terms & Conditions Page.
  • Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER: 14-179

  • Size: 50 uL
  • List Price: $335.00
Datasheet
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